Infrared (IR) Spectroscopy

Aug 01, 2011
Special Issues
By Spectroscopy Editors
Process analytical technology (PAT) and hot-melt extrusion (HME), commonplace in the food and polymer industries, are becoming increasingly deployed in the pharmaceutical industry. Herein the application of in-line, transmission mode, Fourier-transform near-infrared (FT-NIR) spectroscopy to the HME manufacturing platform for a drug product in development is detailed. NIR spectroscopy and partial least squares (PLS) models were developed for real-time active pharmaceutical ingredient (API) loading (%wt/wt) and surfactant loading predictions. These predictions were used for fault detection, isolation of suspect material, and real-time troubleshooting during HME. Additionally, the NIR/PLS output was used for real-time release of the intermediate drug product.
Aug 01, 2011
Special Issues
By Spectroscopy Editors
When combined with the rapid scan speeds of modern instruments, Fourier-transform infrared (FT-IR) spectroscopy provides a powerful real-time method for monitoring chemical changes (for example, the optical adhesive caused by illumination of a UV lamp). This article describes the characterization of several adhesives used in an optical assembly. Several different approaches to measuring the rate of change during the curing experiment are described. As the number of uses for UV curing and photopolymerization increases, real-time FT-IR should play a major role in characterizing these new materials and products.
Jul 01, 2011
Spectroscopy
By Spectroscopy Editors
Simulated leaf spectral data were generated to analyze scattering impact and then compared to experimental data to validate the conclusions of the simulation.
Jun 01, 2011
Spectroscopy
By Spectroscopy Editors
Algae and other aquatic species are promising sources for biomass that can be economically converted into fuel, and several infrared sampling techniques can be used to analyze these samples.
May 01, 2011
Spectroscopy
In the last four columns we described the theory of what should happen when we perform classical least squares calculations on mixtures when Beer's law applies. In this column we take our first look at what actually does happen.
Apr 01, 2011
Special Issues
By Spectroscopy Editors
A review of recent developments in MIR spectroscopy that have potential for field deployment in defense and homeland security applications for standoff detection of highly energetic materials (HEM) and homemade explosives (HME), as well as in forensic sciences applications.
Apr 01, 2011
Special Issues
By Spectroscopy Editors
Combining multiple sensors into one instrument increases the probability of detecting explosive residues and enables the detection of a greater number of explosives.
Apr 01, 2011
Spectroscopy
By Spectroscopy Editors
The wavelet packet transform (WPT) combined with the modified uninformative variable elimination (MUVE) method (WPT–MUVE) is proposed to select variables for multivariate calibration of spectral data.
Feb 11, 2011
Application Notebook
By Spectroscopy Editors
FT-IR diffuse reflectance sampling coupled with an environmental temperature chamber offers a convenient method to study sample degradation, to evaluate catalyst efficiency, and to determine reaction pathways as a function of temperature and pressure.
Feb 11, 2011
Application Notebook
By Spectroscopy Editors
Confocal Raman imaging opened the door for many applications in Raman spectroscopy and imaging that were previously unavailable for measurement with conventional (non-confocal) Raman methods. However, high confocality always results in a high focus sensitivity and this can make measurements difficult with rough or inclined samples.
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