Articles by Waters Corporation - Chromatography Online
Articles by Waters Corporation

Waters NA - Development of a Quantitative UPLC/MS/MS Assay for the Simultaneous Quantification of Acetylcholine, Histamine, and their Metabolites in Human CSF using a CORTECS UPLC HILIC Column to Improve Peak Resolution, Sensitivity, and Speed of Analysis

Oct 24, 2013

The method described herein demonstrates the simultaneous quantification of ACh, HA, and their metabolites in human CSF in a 96-well format. This application uses a single-step sample preparation, dilution of a 20-μL sample, followed by HILIC UPLC/MS/MS analysis. Using a sub-2-μm particle size, the high efficiency CORTECS UPLC HILIC Column provided resolution from endogenous matrices, increased analyte sensitivity, and a short analysis time of 2.5 minutes, thereby resulting in a fast, sensitive, selective, and accurate method that meets the demands of high-throughput bioanalytical drug discovery.

Waters NA - Improved Resolution for Paraquat and Diquat: Drinking Water Analysis Using the CORTECS UPLC HILIC Column

Oct 24, 2013

This application demonstrates the UPLC separation using a CORTECS UPLC HILIC Column to significantly improve the retention and resolution of both analytes, allowing for detection down to 500 ppt by UV detection alone.

Waters EU - Neurotransmitters in Cerebrospinal Fluid

Oct 24, 2013

The method demonstrates the simultaneous quantification of ACh, HA, and their metabolites in human CSF in a 96-well format. This application uses a single-step sample preparation followed by HILIC UPLC/MS/MS analysis. The high efficiency CORTECS UPLC HILIC Column provided resolution from endogenous matrices, increased analyte sensitivity, and a short analysis time of 2.5 minutes, thereby resulting in a fast, sensitive, selective, and accurate method that meets the demands of high-throughput bioanalytical drug discovery.

Neurotransmitters in Cerebrospinal Fluid

Oct 24, 2013

The method demonstrates the simultaneous quantification of ACh, HA, and their metabolites in human CSF in a 96-well format. This application uses a single-step sample preparation followed by HILIC UPLC/MS/MS analysis. The high efficiency CORTECS UPLC HILIC Column provided resolution from endogenous matrices, increased analyte sensitivity, and a short analysis time of 2.5 minutes, thereby resulting in a fast, sensitive, selective, and accurate method that meets the demands of high-throughput bioanalytical drug discovery.

Waters EU - Method Development for Impurity Analysis

Oct 22, 2013

The ACQUITY QDa Detector aids in the development of efficient and robust screening methods by minimizing the need for standard runs to confirm the identity of peaks by retention time.

Waters EU - Synthetic Cannabinoids from Whole Blood

Sep 23, 2013

This application note details a strategy for the successful extraction and analysis of representatives of several different classes of synthetic cannabinoids from whole blood samples for forensic toxicology. Twenty-two synthetic cannabinoids and metabolites were extracted from whole blood samples using a rapid and universal sample preparation strategy that provides effective sample cleanup and is generic enough to use on a variety of compounds with different chemical properties.

Waters NA - Synthetic Cannabinoids from Whole Blood

Sep 23, 2013

This application note details a strategy for the successful extraction and analysis of representatives of several different classes of synthetic cannabinoids from whole blood samples for forensic toxicology. Twenty-two synthetic cannabinoids and metabolites were extracted from whole blood samples using a rapid and universal sample preparation strategy that provides effective sample cleanup and is generic enough to use on a variety of compounds with different chemical properties.

Waters NA - Lipid Class Separation Using UPC2/MS

Sep 12, 2013

A flexible, universal method was developed for the analysis of inter-class separations of neutral and amphipathetic lipids.

Waters NA - Comparing Orthogonality of Convergence Chromatography to Reversed-Phase LC

Sep 12, 2013

Application examples have proven convergence chromatography to be an effective orthogonal separation technique to commonly used reversed-phase LC. UPC2 provides a different elution order than RPLC, which is critical for resolving all peaks in a sample.

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