Articles by Waters Corporation - Chromatography Online
Articles by Waters Corporation

Waters EU - Utilization of UPLC and Empower 2 CDS for Efficient Method Development of an Impurity Profile of Simvastatin and Related Impurities

Sep 29, 2014

There are several methods for analyzing simvastatin and its related impurities. Two official methods utilizing HPLC gradient methodology are reported in the EP and USP. These methodologies are typically time-consuming, with analysis times in excess of 30 min. To meet the business needs of a generic pharmaceutical company, a faster methodology is required that does not compromise analytical quality.

Waters NA - Biopharmaceutical Platform Solution with UNIFI - Key Applications

Sep 26, 2014

The Biopharmaceutical Platform Solution with UNIFI enables laboratories to efficiently acquire, process, and communicate information from high resolution analytical studies. Accomplish the most basic bioseparations to the most complex LC/MS characterization studies using a single integrated technology platform. Addressing common workflows for intact mass, peptide mapping, and glycan analysis with modern tool sets for reporting and compliance management, the UNIFI platform can bring efficiency and productivity to labs from discovery thru QC.

Waters NA - Utilization of UPLC and Empower 2 CDS for Efficient Method Development of an Impurity Profile of Simvastatin and Related Impurities

Sep 26, 2014

There are several methods for analyzing simvastatin and its related impurities. Two official methods utilizing HPLC gradient methodology are reported in the EP and USP. These methodologies are typically time-consuming, with analysis times in excess of 30 minutes. To meet the business needs of a generic pharmaceutical company, a faster methodology is required that does not compromise analytical quality.

Waters NA - 21 CFR Part 11 Readiness of Empower 3

Sep 26, 2014

Meeting 21 CFR Part 11 compliance remains challenging; however, e-record regulations will eventually be viewed as a significant driver to move companies from a paper-records environment to a more efficient electronic-records environment. Although it is understood that merely purchasing a chromatography data software package that incorporates Part 11 technical controls does not make one fully compliant, technical controls should be inherent in any system used in a regulated environment. A suite of technical controls for 21 CFR Part 11 compliance are built into Empower 3 Software to simplify administration and allow laboratories to meet the U.S. and European regulations.

Waters NA - Is it Time to Replace Your CDS?

Sep 26, 2014

Learn about the three main drivers for considering a new chromatography data system (CDS) and how your lab can benefit. Obtain guidance in making the decision to replace an existing CDS and get practical "factors to consider" that address common concerns.

Waters NA - Combining Mass and UV Spectral Data with Empower 3 Software to Streamline Peak Tracking and Coelution Detection

Sep 26, 2014

Methods development using a single detection technique can be challenging. UV spectral data can assist in peak purity and identification however it is difficult to perform peak tracking in the presence of coelutions. Mass spectral data can be used to match chromatographic peaks to items on a short list of compounds, but the presence of isobaric compounds can require additional information: complete separation is typically required and not only allows for immediate identification based on the UV but also more reliable quantification. Typically, identifying these phenomena requires further analyses. For simplified methods development, a chromatographic system using both UV and mass detection and a streamlined software platform can be combined to evaluate peak purity and assist in the identification of coelutions in a single run.

Waters NA - Using the Elucidation Tool in UNIFI Scientific Information System to Identify Unknown Compounds in Natural Products

Sep 26, 2014

To identify components from a sample that either were not matched with scientific libraries within the UNIFI Scientific Information System, or were matched but were suspected to be false positive, the Elucidation Tool within the UNIFI can be used. An example is used to demonstrate the process using the Natural Product Application Solution with UNIFI.

Waters NA - A Reproducible Method for the Quantification of Pioglitazone and Metabolites in Human Plasma Using the ACQUITY UPLC H-Class System and Xevo TQD MS with UNIFI

Sep 26, 2014

A high sensitivity method was developed for the analysis of pioglitazone and its two active metabolites, keto pioglitazone and hydroxy pioglitazone, in human plasma. The extremely low carryover exhibited by the ACQUITY UPLC H-Class System allows the full sensitivity of the Xevo TQD Mass Spectrometer to be utilized.

Waters NA - A Label-Free, Multi-Omic Study to Qualitatively and Quantitatively Characterize the Effects of a Glucosylceramide Inhibitor on Obesity

Sep 26, 2014

A label-free, multi-omics approach provided qualitative and quantitative information in a single experiment to help characterize and investigate the effects of a glucosylceramide inhibitor for treatment of obesity. Progenesis QI and Progenesis QI for Proteomics Software enabled a seamless workflow, from LC-MS data processing and database searching to pathway interrogation, implicating carbohydrate metabolism, and molecular transport networks in the compound’s mechanism of action.

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LCGC COLUMNISTS 2014

Column Watch: Ron Majors, established authority on new column technologies, keeps readers up-to-date with new sample preparation trends in all branches of chromatography and reviews developments. LATEST: When Bad Things Happen to Good Food: Applications of HPLC to Detect Food Adulteration


Perspectives in Modern HPLC: Michael W. Dong is a senior scientist in Small Molecule Drug Discovery at Genentech in South San Francisco, California. He is responsible for new technologies, automation, and supporting late-stage research projects in small molecule analytical chemistry and QC of small molecule pharmaceutical sciences. LATEST: HPLC for Characterization and Quality Control of Therapeutic Monoclonal Antibodies


MS — The Practical Art: Kate Yu brings her expertise in the field of mass spectrometry and hyphenated techniques to the pages of LCGC. In this column she examines the mass spectrometric side of coupled liquid and gas-phase systems. Troubleshooting-style articles provide readers with invaluable advice for getting the most from their mass spectrometers. LATEST: Radical Mass Spectrometry as a New Frontier for Bioanalysis


LC Troubleshooting: LC Troubleshooting sets about making HPLC methods easier to master. By covering the basics of liquid chromatography separations and instrumentation, John Dolan is able to highlight common problems and provide remedies for them. LATEST: How Much Can I Inject? Part I: Injecting in Mobile Phase


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