Mass Spectrometry

Mar 01, 2016
Special Issues
This article provides useful tips for smooth validation of multi-analyte LC–MS-MS methods and summarizes important validation outcomes for 295 analytes, including more than 200 mycotoxins.
Mar 01, 2016
Special Issues
Enhanced chromatographic resolution (GC×GC), increased resolving power with high-resolution TOF-MS, and software designed to leverage these attributes are combined to provide data that are easy to process and interpret.
Mar 01, 2016
Special Issues
An LC–MS-MS method is presented that can assist with monitoring substance abuse patients who are prescribed naltrexone, a narcotic antagonist.
Mar 01, 2016
Special Issues
This article presents a step-by-step DoE optimization strategy for an electrospray ionization source with the aim to quantitatively analyze 18 compounds in a metabolomic study of human urine.
Jul 01, 2015
Special Issues
To translate the enormous potential of MS into meaningful, actionable, and safe test results in the specific setting of a clinical laboratory is a very substantial challenge. It is essential to realize that reliability is not inherent to this technology but must be addressed carefully and questioned systematically.
Oct 01, 2014
Special Issues
A multiresidue method has been developed and validated for the analysis of methylxanthines (caffeine and its metabolites) and cotinine in human plasma.
Oct 01, 2014
Special Issues
By Spectroscopy Editors
This article describes the development of a new data-independent acquisition (DIA) workflow for protein quantification that uses a mass spectrometer that combines three types of mass analyzers to achieve lower limits of detection (LOD), higher sensitivity, more accurate quantitative results, wider dynamic range, and better reproducibility than existing high-resolution accurate-mass (HRAM) tandem mass spectrometry (MS-MS) DIA workflows.
Oct 01, 2014
Special Issues
In most countries, herbal medicinal products (HMPs) are introduced into the market without proper scientific evaluation or enforced safety and toxicological studies.
Oct 01, 2014
Special Issues
By Spectroscopy Editors
Worldwide trends in illicit drug use and production have shifted toward an increase in synthetic analogues and the emergence of new variations in their manufacture.
Oct 01, 2014
Special Issues
By Spectroscopy Editors
We recently spoke to Gary Duncan and Wendy Russell of the Rowett Institute of Nutrition & Health in Aberdeen, Scotland, about the significance of phytochemical bioavailability to human health and the important role of liquid chromatography linked to tandem mass spectrometry (LC–MS-MS) in their research.
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