Special Issues-06-02-2005

Special Issues

Combining Confocal Raman with Atomic force Microscopy for High-Resolution Material Analysis

June 02, 2005

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Confocal Raman microscopy can be useful when applied to all samples that are heterogeneous on the micrometer to millimeter scale and that generally can be investigated by Raman spectroscopy. This article presents examples of confocal Raman microscopy from various fields of application including pharmaceutical analysis and stress measurements in semiconductors.

A New Approach to Simultaneous Raman and IR Spectral Searches

June 02, 2005

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A new system for multitechnique spectral searching is described that utilizes analysis of several hit lists resulting from spectral similarity searches performed simultaneously in reference databases for multiple complementary analytical techniques. This paper demonstrates the benefits of this multitechnique approach using the complementary techniques of IR and Raman spectroscopy.

Raman and EDXRF Chemical Imaging for Formulation Process Development and Quality Control

June 02, 2005

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Compounds of magnesium and calcium are common components of pharmaceutical formulations. Spectroscopic imaging can provide a complete understanding of a formulation. This paper compares two spectral imaging techniques — energy dispersive X-ray fluorescence (EDXRF) microscopy and Raman microscopy.

Grating Corrected Laser Stabilization: A Case Study in Pharmaceutical Raw Material Identification

June 02, 2005

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The authors present a novel technique for obtaining very high stability and reproducibility of a Raman spectrum, using grating corrected laser stabilization. An externally stabilized laser with a grating spectrometer provides exceptional quantum efficiency in the entire dynamic range. These components then are used to build a library of pharmaceutical raw materials and tested on samples of unknown material.

Raman Microanalysis in the Forensic Laboratory: Identification and Characterization of Suspect Solids, Liquids, and Powders

June 02, 2005

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Due to its high information, vibrational content, the Raman spectrum provides important and specific molecular information. In this article, Raman microanalysis and instrumentation is discussed with specific application to the forensic science laboratory, where evidence integrity is of the utmost importance.

Reliable Substrate Technology for Surface-Enhanced Raman Spectroscopy

June 02, 2005

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The acquisition of Raman spectra can be eased greatly through the use of surface-enhanced Raman spectroscopy (SERS). In this article, the authors discuss a new substrate technology that delivers reliable and consistent surface enhancement.

Detecting Bacillus Spores by Raman and Surface-Enhanced Raman (SERS) Spectroscopy

June 02, 2005

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Raman spectroscopy has been employed to detect Bacillus cereus spores, an anthrax surrogate, collected from a letter as it passed through a mail sorting system. Raman spectroscopy also has the ability to identify many common substances used as hoaxes. A three-step method also is described for the detection of dipicolinic acid extracted from surface spores by SERS.

Comparing Standard CCD and Electron Multiplication CCD for Low Light Level Spectroscopy

June 02, 2005

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This article compares different CCD platforms by outlining CCD and EMCCD noise sources as well as an explanation of the two calculations to arrive at the signal-to-noise ratio for each. The data presented will show that a liquid nitrogen-cooled CCD camera still is the proper choice for low light level applications, such as Raman spectroscopy.