Special Issues-10-01-2017

Special Issues

Gas Chromatography–Mass Spectrometry Characterization of Vegetable Oil–Derived Potent Antimicrobial Agents

October 01, 2017

Articles

15

4

Under a suitable thermal oxidation regime, vegetable oils yield a mixture of volatile and semivolatile organics that exhibit very high antimicrobial activities against a variety of microbial species. Volatile and semivolatile products were characterized with GC–MS using electron ionization and chemical ionization. The thermal oxidation of vegetable oils resulted in the formation of an array of shortand medium-chain acids, aldehydes, and ketones that act synergistically to yield a potent antimicrobial disinfectant.

Mass Spectrometry Techniques to Unravel the Heterogeneity of Glycoproteins

October 01, 2017

Articles

15

4

Since glycans are responsible for bioactivity, solubility, immunogenicity, and clearance rate from circulation, it is vital to have a detailed map of glycans in therapeutic glycoproteins. Detailed glycoprotein structural analysis must be able to identify the peptide sequence where the glycans are attached as well as the structure of the glycan portion, including oligosaccharide sequence and glycosyl linkages. This article details methods for mass spectrometry experiments on both released glycans (“glycomics”), as well as on intact glycopeptides (“glycoproteomics”) using electron transfer dissociation, high-energy collision dissociation, and collisioninduced dissociation fragmentation pathways, which are needed to fully elucidate the structure of glycoproteins.

Applying LC with Low-Resolution MS/ MS and Subsequent Library Search for Reliable Compound Identification in Systematic Toxicological Analysis

October 01, 2017

Articles

15

4

Systematic toxicological analysis is an important step in medicolegal investigations of death, poisoning, and drug use. The primary goal is the detection and confirmation of potentially toxic compounds in evidence. This article describes a workflow using nontargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) for reliable compound identification.

Vol 15 No 4 Current Trends in Mass Spectrometry October 2017 Issue PDF

October 01, 2017

Issue PDF

15

4

Click the title above to open the October 2017 issue of Current Trends in Mass Spectrometry, Volume 15, Number 4, in an interactive PDF format.