ICP-MS

Nov 01, 2010
Special Issues
By Spectroscopy Editors
Recently, the attention of the U.S. Pharmacopeia (USP) has turned to the elemental impurities found in drug products. Before its most recent activities, USP methods for determining elemental impurities have relied upon outdated methodology that is qualitative, relatively insensitive, and can be used only for the determination of a subset of the toxic elements that should be quantified (USP Chapter <231> - Heavy Metals). Proposed changes have been made that utilize modern analytical techniques for measuring a larger number of heavy metals at toxicologically relevant concentrations. As of this publication, the expected date for implementing changes to USP Chapter <231> is September 2013.
Nov 01, 2010
Special Issues
By Spectroscopy Editors
Almost all current quadrupole ICP-MS systems use collision/reaction cell technology to reduce polyatomic interferences, but the effectiveness of these devices for the removal of unexpected interferences remains a contentious issue. Here, we demonstrate that helium cell mode operation on the instrument described provides an opportunity for analysts to report reliable multielement data from complex, variable, and unknown matrices, using a single He mode method for all required analytes.
Nov 01, 2010
Special Issues
By Spectroscopy Editors
Technology in the manufacture of instruments has evolved by leaps and bounds in the past few decades. The capability of these instruments to measure and quantify concentration at picogram levels has made the analyst more aware of trace contaminants unintentionally introduced during analysis. By raising awareness of contamination issues and sources, it is hoped that analysts can take an active role in reducing error in their ICP and ICP-MS analyses.
May 01, 2009
Spectroscopy
By Spectroscopy Editors
Guest columnist Steven Wilbur discusses the elemental nature of ICP-MS and its strength as a universal quantifier, an aspect of the technique he believes has not received enough attention.
Feb 01, 2009
Application Notebook
The authors discuss the use of ICP-MS as an effective chromatographic detection method that is relatively easy to interface to gas chromatography for gas analysis.
Feb 01, 2009
LCGC North America
The authors investigate applications for ICP-MS detection with reversed-phase HPLC.
Jan 01, 2009
Spectroscopy
By Spectroscopy Editors
The coupling of HPLC with ICP-MS is a relatively new technique that combines two very well established analytical methods. The combination of these analytical methods provides what could prove to be a very useful technique in clinical analysis. The total LC-ICP-MS market amounts to only a few percent of the overall ICP-MS market, but it is rapidly developing into a significant niche market.
Jan 01, 2009
Spectroscopy
By Spectroscopy Editors
Columnist Ken Busch discusses the ability to "dial in" resolving power as needed in newer trap mass analyzers, which shows promise for speciation analysis in ICP-MS with chromatographic separation of sample components.
Nov 01, 2008
Spectroscopy
By Spectroscopy Editors
The authors discuss the use of ICP-MS as an effective chromatographic detection method that is relatively easy to interface to gas chromatography for gas analysis.
Oct 01, 2008
Special Issues
In this article, the author describes the components available for the "front end" of an inductively coupled plasma spectrometer and discusses the pros and cons of each.
native1_300x100
lorem ipsum