Interview of the Month

Detecting Engineered Nanoparticles in Environmental Samples

The use of engineered nanoparticles (ENPs) in various applications and consumer products continues to increase, and these nanoparticles require thorough characterization for proper environmental risk assessment. James Ranville, a professor at the Colorado School of Mines, in Golden, Colorado, has been studying colloids and and particles in environmental processes and developing methods to collect and analyze colloids from rivers, reservoirs, mountain streams, soil solutions, and ground waters. He spoke with us about his work using field-flow fractionation–inductively coupled plasma mass spectrometry (FFF-ICP-MS) and ICP-MS for the detection of engineered nanoparticles in environmental samples.


Spectroscopy Announces the First Winner of the Emerging Leader in Molecular Spectroscopy Award

By Spectroscopy Editors

Matthew Baker, a senior lecturer in chemistry at the University of Strathclyde, in Glasgow, has won the inaugural Emerging Leader in Molecular Spectroscopy Award, which is sponsored by Spectroscopy magazine. This new annual award recognizes the achievements and aspirations of a talented young molecular spectroscopist, selected by an independent scientific committee. The award will be presented to Baker at the SciX 2016 conference in September, where he will give a plenary lecture and be honored in an award symposium.

A Process for Successful Infrared Spectral Interpretation

By Brian C. Smith

A 12-step program to help you be more successful at interpreting IR spectra

Advancing the Application of NIR Spectroscopy

By Spectroscopy Editors

Although near-infrared (NIR) spectroscopy is not a particularly sensitive technique, it can be implemented with little or no sample preparation and thus is well suited to applications such as process monitoring, materials science, and medical uses. We asked a panel of experts to comment on important current applications of NIR, as well as emerging new areas of application and the challenges involved in those newer applications.

In Situ FTIR Analysis of Soils for Forensic Applications

By A.H. Jean Robertson, Angela M. Main, Lucinda J. Robinson, Lorna A. Dawson

Although handheld FT-IR spectrometers now make it possible to carry out field-based FT-IR analysis of soils at a crime scene, reliable and tested protocols are not yet available for such work. Here, we discuss sampling options and describe tests of a methodology that is being eveloped for in situ FT-IR analysis of soil samples.

Using Near-Infrared Spectroscopy to Monitor the Curing Reaction of Silicone Adhesives

By N. Pemberger, L.K.H. Bittner, C. W. Huck

Quality control of silicones used in medicinal implants is challenging, and traditional methods waste a lot of raw material. In this study, NIR spectroscopy has been used to replace the traditional rheometric measurements, with excellent results. The NIR method enables improved quality control and a more economical process.


Using SERS to Study How Cells Respond to Pharmaceuticals

By Spectroscopy Editors

Colin Campbell discusses his work applying SERS to biomedical applications.

Polarized Raman Spectroscopy of Aligned Semiconducting Single-Walled Carbon Nanotubes

By Amir Mashal, Dick Wieboldt, Katherine Jinkins, Michael S. Arnold

A look at how polarized Raman imaging can be used to characterize alignment in large regions of aligned semiconducting carbon nanotube films.

Recent Developments in Handheld Raman Spectroscopy for Industry, Pharma, Forensics, and Homeland Security: 532-nm Excitation Revisited

By Aleksandr V. Mikhonin, Susan Hodi, Laurence A. Nafie, Rina K. Dukor

Handheld Raman using 532-nm excitation is an effective option for field analysis, in applications ranging from the analysis of biopharmaceuticals to explosive detection.

Raman Spectroscopy as a Tool for Analytical Quality Control in a Hospital Environment

By Karen A. Esmonde-White

Two applications of Raman spectroscopy in a hospital environment are reviewed: analytical quality control for compounded formulations and gas analysis during general anesthesia.


Overview of High-Efficiency Transmission Gratings for Molecular Spectroscopy

By Thomas Rasmussen

This article provides a basic overview of the capabilities of transmission gratings optimized for molecular spectroscopy.

Scattering Impact Analysis and Correction for Leaf Biochemical Parameter Estimation Using Vis–NIR Spectroscopy

By Qianxuan Zhang, Qingbo Li, Guangjun Zhang

Simulated leaf spectral data were generated to analyze scattering impact and then compared to experimental data to validate the conclusions of the simulation.

An Integration of Modified Uninformative Variable Elimination and Wavelet Packet Transform for Variable Selection

By Di Wu, Xiaojing Chen, Yong He

The wavelet packet transform (WPT) combined with the modified uninformative variable elimination (MUVE) method (WPT–MUVE) is proposed to select variables for multivariate calibration of spectral data.

Analysis of Fructose, Glycine, and Triglycine Using HPLC UV-vis Detection and Evaporative Light-Scattering Detection

By A.B. de Haan, R. Wijntje, H.A.J.M. Bevers

The development of a method for the simultaneous determination of glycine, triglycine and fructose using UV–vis and evaporative light-scattering detection (ELSD) is described. This was necessary as part of a research project dealing with the recovery of functional peptides from aqueous streams on an industrial scale using adsorption or related technologies. Fructose is barely detectable by UV–vis as it lacks detectable functionalities, while glycine and triglycine are both UV–vis sensitive. An NH2 phase was chosen as a column and separation was obtained within seven minutes on a 250 X 4.6 mm column. Limits of detection are approximately 40 mg fructose/L, 4 mg glycine/L and 0.05 mg triglycine/L. Calibration functions are linear in a range of 40–1400 mg/L for fructose, 5–200 mg/L for glycine and 0.5–70 mg/L for triglycine.

Spectroscopy in Space: Hubble and the Cosmic Origins Spectrograph

By Spectroscopy Editors

In an upcoming spacewalk, shuttle astronauts will swap the Corrective Optics Space Telescope Axial Replacement (COSTAR) device for the new Cosmic Origins Spectrograph (COS).

Peer-Reviewed Articles

Emerging Trends and Opportunities in Discrete-Frequency Infrared and Raman Spectroscopic Imaging

By Tomasz P. Wrobel, Matthew R. Kole, Rohit Bhargava

Recent advances in instrumentation have enabled new forms of vibrational chemical imaging, including discrete-frequency infrared (DFIR) microscopy and stimulated Raman scattering (SRS) microscopy. These technologies may represent a fundamental shift in how we approach spectroscopic imaging.

Preparation of Pharmaceutical Samples for Elemental Impurities Analysis: Some Potential Approaches

By Nancy Lewen

As analysts prepare to meet the requirements of the new United States Pharmacopeia and International Conference on Harmonization standards on elemental impurities, they need to understand how to choose the most suitable sample preparation approach.


Indiana University School of Informatics and Computing Awarded $1M Grant from NIH

The National Institutes of Health (NIH) has awarded $1.18 million to faculty at the Indiana University School of Informatics and Computing at Indiana University–Purdue University Indianapolis and the IU School of Medicina (Indianapolis, Indiana) for a research collaboration that unites two cutting-edge technologies in the discovery and analysis of proteoforms.

Proceeds from Pittcon 2016 Award Grants to Fund Science Education Grants at the Elementary, High School, and College Levels

Proceeds from Pittcon 2016 are distributed by its sponsoring societies, the Society for Analytical Chemists of Pittsburgh (SACP), and the Spectroscopy Society of Pittsburgh (SSP).

Spectroscopy at Analytica

Analytica 2016, held this week in Munich, includes strong programming in spectroscopy techniques. Two sessions—one on modern analytical spectroscopy and another on bioprocessing monitoring—are entirely dedicated to spectroscopy.


What Modeling Reveals About the Properties of an Inductively Coupled Plasma

By Spectroscopy Editors

Annemie Bogaerts and Maryam Aghaei of the University of Antwerp, Belgium, are carrying out computational modeling to examine how various properties of the ICP, such as gas flow path lines and ionization effects, are affected by various factors—such as gas flow rates, applied power, and even the very presence of a mass spectrometry sampler. Using their developed model, one can predict optimum conditions for specific analyses.

How to Improve Analytical Figures of Merit of Hard-To-Ionize Elements in ICP-Based Techniques

By Spectroscopy Editors

Matrix effects in ICP-OES and ICP-MS often cause signal suppression, but can lead to signal enhancement as well. Guillermo Grindlay of the University of Alicante, in Spain, discusses his work to better understand under what conditions these matrix effects occur and what mechanisms are involved.

Questioning the Relationship Between Analyte Ion Mass and ICP-MS Matrix Effects

By Spectroscopy Editors

New studies conducted by Shi Jiao and John Olesik at The Ohio State University have important implications for understanding the fundamental causes of matrix effects in ICP-MS, and for the choice of internal standards.

Determining Trace Elements in Edible Oils Using Inductively Coupled Plasma–Optical Emission Spectrometry

By Manuel Almeida, Karolina Carpenter

During the processing of edible oils, the analysis of trace metals, which can promote oxidation, is important. This article presents a study of metals in edible oils using radial-view ICP-OES and discusses the most suitable wavelengths, background correction, and integration times.

Sample Preparation Method for Mercury Analysis in Reagent Chemicals by ICP-OES

By Yogesh Parikh, Samantha Mahmoud, James Lallo, Huifang Lang

This study shows that a direct Au3+ and HCl sample preparation method quickly and simply allows for accurate Hg quantification by ICP-OES in a wide range of sample types.

Mass Spectrometry

Review of the 64th Conference on Mass Spectrometry and Allied Topics

By Cindy Delonas

We present a brief review of this year's ASMS conference, which took place June 5–9 in San Antonio, Texas.

Sensitive, Rapid Estimation of Moxidectin in Cattle Hair by LC–MS-MS

By P. Sambasivarao, Raman Batheja, N. Subbarao, S. Ashma, K. Ashwini, M. Mupeksha

Validation of this rapid bioanalytical method for the determination of moxidectin in cattle hair demonstrated that the method is accurate, reliable, and reproducible.

The Applicability of Field-Portable GC–MS for the Rapid Sampling and Measurement of High-Boiling-Point Semivolatile Organic Compounds in Environmental Samples

By Tai Truong, Nathan Porter, Ed Lee, Robert J. Thomas

A look at the use of field-portable GC–MS with solid-phase microextraction, purge-and-trap, thermal desorption, and heated headspace sampling techniques to provide a fast response for in-field analysis of SVOCs in a wide variety of environmental-type samples including potable waters, tea, plants, and road gravel.

Comparison of LC–MS and GC–MS for the Analysis of Pharmaceuticals and Personal Care Products in Surface Water and Treated Wastewaters

By Blake Rushing, Ashley Wooten, Marcus Shawky, Mustafa I. Selim

This study of a selected group of PPCP contaminants in eastern North Carolina demonstrates the advantages and disadvantages of LC–MS and GC–MS as well as SPE and liquid–liquid extraction.

Review of the 64th Conference on Mass Spectrometry and Allied Topics

By Cindy Delonas

We present a brief review of this year's ASMS conference, which took place June 5–9 in San Antonio, Texas.

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