Nick Riley is the winner of the FACSS Student Award at SciX 2017. He earned his B.S. degree in chemistry and psychology from the University of South Carolina (Columbia, South Carolina) with honors from the South Carolina Honors College, where he was a Robert C. McNair Scholar. He conducted undergraduate research in forensic analytical chemistry with Dr. Stephen L. Morgan and developed a fascination for the instrumentation he used while in the Morgan laboratory.
Nick Riley is the winner of the FACSS Student Award at SciX 2017. He earned his B.S. degree in chemistry and psychology from the University of South Carolina (Columbia, South Carolina) with honors from the South Carolina Honors College, where he was a Robert C. McNair Scholar. He conducted undergraduate research in forensic analytical chemistry with Dr. Stephen L. Morgan and developed a fascination for the instrumentation he used while in the Morgan laboratory.
Following graduation, he moved to Madison, Wisconsin, to join the laboratory of Joshua J. Coon as an analytical chemistry graduate student at the University of Wisconsin. In his tenure there, Riley has conducted research in the field of bioanalytical mass spectrometry (MS) with a focus on developing instrumentation and methodologies to improve characterization of protein post-translational modifications in complex systems. The majority of his work has centered on improving the efficacy of electron transfer dissociation (ETD) and related tandem MS techniques. Through the use of infrared photoactivation concurrent with ion–ion reactions, Nick has significantly enhanced the capabilities of ETD to sequence peptide and protein ions in high-throughput proteomic experiments, and the scope of this exciting technology is just beginning to be explored. Throughout his graduate career Riley has worked on globally characterizing protein acetylation and phosphorylation, but his most recent efforts have focused on protein glycosylation, a chemically complex and analytical challenging modification involved in a wide array of intra- and intercellular functions. Riley’s work with ETD and hybrid tandem MS methods is among the first efforts to characterize thousands of glycosites via intact glycopeptides, providing crucial site-specific biological context at an unprecedented scale. He is now continuing to develop this technology to investigate glycosylation profiles in models of cancer aggressiveness to understand cancer cell metastasis.
Getting accurate IR spectra on monolayer of molecules
April 18th 2024Creating uniform and repeatable monolayers is incredibly important for both scientific pursuits as well as the manufacturing of products in semiconductor, biotechnology, and. other industries. However, measuring monolayers and functionalized surfaces directly is. difficult, and many rely on a variety of characterization techniques that when used together can provide some degree of confidence. By combining non-contact atomic force microscopy (AFM) and IR spectroscopy, IR PiFM provides sensitive and accurate analysis of sub-monolayer of molecules without the concern of tip-sample cross contamination. Dr. Sung Park, Molecular Vista, joined Spectroscopy to provide insights on how IR PiFM can acquire IR signature of monolayer films due to its unique implementation.
Deep Level Transient Spectroscopy Reveals Influence of Defects on 2D Semiconductor Devices
April 25th 2024A recent study used deep level transient spectroscopy to investigate the electrical response of defect filling and emission in monolayer metal-organic chemical vapor deposition (MOCVD)-grown materials deposited on complementary metal-oxide-semiconductor (CMOS)-compatible substrates.
Single Cell and Microplastic Analysis by ICP-MS with Automated Micro-Flow Sample Introduction
April 25th 2024Single cell ICP-MS (scICP-MS) is increasingly seen as a powerful and fast tool for the measurement of elements in individual cells, mainly due to the high sensitivity and selectivity of ICP-MS. Analysis is performed in the same way as single nanoparticle (spICP-MS) analysis, which has become a well-established technique for the analysis of nanoparticles and particles.
Hot News on Agilent LDIR, New Developments, and Future Perspective
April 25th 2024Watch this video featuring Darren Robey and Dr. Wesam Alwan from Agilent Technologies to gain insights into the future trends shaping microplastics research and the challenges of their characterization. Discover the essential components necessary for accurate microplastics analysis and learn how the Agilent 8700 LDIR system addresses these challenges. Offering rapid and precise analysis capabilities, along with easy sample preparation methods that minimize contamination, the Agilent 8700 LDIR system is at the forefront of advancing microplastics research.