Authors
Latest:
Using High-Resolution LC–MS to Analyze Complex SampleThe authors discuss the use of high-resolution LC-MS to analyze complex samples in regulated environments such as food and animal-feed analysis.
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Investigation of Transferrin Structure via Novel Electron Capture Dissociation Techniques Using a Hybrid Linear Ion Trap Time-of-Flight Mass SpectrometerThe authors discuss the use of electron-capture dissociation coupled with a linear ion trap time-of-flight mass spectrometer to investigate the structure of human transferrin.
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Comparison of Quadrupole, Time-of-Flight, and Fourier Transform Mass Analyzers for LC-MS Applications (PDF)The authors investigated the analytical capabilities of three types of mass analyzers for liquid chromatography-mass spectrometry (LC-MS) applications, studying the effects of instrument parameters and issues related to sample preparation on the performance of LC-MS analytical methods.
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Comprehensive Screening, Confirmation, and Quantification of Organic Pesticides in Foods by GC–MS and LC–MSThis article provides an overview of the instrument platforms, tools, and workflow for analyzing pesticides.
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From Tablets to Teeth: Complete Raman ImagingRaman imaging has moved on. It is now possible to capitalize on the wealth of information available from a Raman spectrum by imaging materials over large areas, with the spatial resolution, spectral resolution, and laser excitation parameters tailored to suit each application. Raman experiments and images from a diverse range of samples are presented.
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An Investigation into the Use of Alternate Carrier Gases for the Determination of Volatile Organic Compounds in Water by GC–MSThis study focuses on United States Environmental Protection Agency (US EPA) Method 524.3 for volatile organic compounds (VOCs) in water using gas chromatography–mass spectrometry (GC–MS).
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Investigation of Transferrin Structure via Novel Electron Capture Dissociation Techniques Using a Hybrid Linear Ion Trap Time-of-Flight Mass SpectrometerThe authors discuss the use of electron-capture dissociation coupled with a linear ion trap time-of-flight mass spectrometer to investigate the structure of human transferrin.
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A Robust and Sensitive Method for Detecting Glyphosate and Other Polar Pesticides in Food and Water: Multiple Analytes in a Single Injection without DerivatizationA new high-throughput LC–MS/MS method meets the challenge of eliminating matrix effects for monitoring, with high specificity, polar organic pesticides such as glyphosate in food and water, while meeting targeted limits of detection.
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LC–MS-MS Determination of Malachite Green and Leucomalachite Green in Fish ProductsAlthough not currently used in U.S. or European aquaculture, malachite green (MG) is still an effective and inexpensive fungicide that is used in other countries, particularly in Asia. During metabolism, MG reduces to leucomalachite green (LMG) (Figure 1), which has been shown to accumulate in fatty fish tissues. Trace levels of MG and LMG residues continue to be found in fish products. In a 2005 report, MG was found in 18 out of 27 live eel or eel products imported from China to Hong Kong local market and food outlets, resulting in a government recall and destruction of all remaining products (1).
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Simple and Effective Control of Spectral Overlap Interferences in ICP-MSThe authors discuss a new approach to the control of spectral overlap interferences in inductively coupled plasma–mass spectrometry.
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Posttranslational Modification Characterization via Electron Capture Dissociation Using a Linear Ion Trap Time-of-Flight Mass SpectrometerThe authors introduce a compact ECD device coupled to a linear ion trap time-of-flight instrument, and use it to analyze protein phosphorylation in both offline and online modes.
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Depth Profiling with Confocal Raman Microscopy, Part II (PDF)Part II of the two-part series continues the discussion on the interpretation of confocal Raman data, including how depth resolution is degraded when focusing deep within a sample and how intensity variations can occur when focusing near a sample's surface.
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Accelerated Discovery and Quantitation of Lipids in Complex ExtractsThe authors discuss analytical methods for lipidomics.
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Extraction of a Full Suite of Semivolatile Compounds from Drinking Water Using Automated Solid-Phase ExtractionDrinking water is an important part of environmental exposure, especially for small children. Countries around the world have put regulations in place to monitor drinking water quality for a wide range of hazardous compounds.
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High Resolution 1H NMR Spectroscopy of Metabolically Active Microorganisms Using Non-Destructive Magic Angle Spinning (PDF)The authors show that high resolution 1H nuclear magnetic resonance (NMR) spectroscopy can be used to study biofilm metabolism under environmentally relevant conditions in a minimally invasive way.
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LC–MS-MS Determination of Malachite Green and Leucomalachite Green in Fish ProductsAlthough not currently used in U.S. or European aquaculture, malachite green (MG) is still an effective and inexpensive fungicide that is used in other countries, particularly in Asia. During metabolism, MG reduces to leucomalachite green (LMG) (Figure 1), which has been shown to accumulate in fatty fish tissues. Trace levels of MG and LMG residues continue to be found in fish products. In a 2005 report, MG was found in 18 out of 27 live eel or eel products imported from China to Hong Kong local market and food outlets, resulting in a government recall and destruction of all remaining products (1).
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Current Status of Standoff LIBS Security Applications at the United States Army Research LaboratoryThe United States Army Research Laboratory (ARL) has been applying standoff laser-induced breakdown spectroscopy (LIBS) to hazardous material detection and determination. We describe several standoff systems that have been developed by ARL and provide a brief overview of standoff LIBS progress at ARL. We also present some current standoff LIBS results from explosive residues on organic substrates and biomaterials from different growth media. These new preliminary results demonstrate that standoff LIBS has the potential to discriminate hazardous materials in more complex backgrounds.
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Multitargeting PesticidesThe usefulness of liquid chromatography–mass spectrometry–mass spectrometry (LC–MS-MS) methods for the unambiguous identification and quantification of pesticides in complex matrix samples is well known. Triple-quadrupole systems have proven to be useful for this task because of their high specificity in MS-MS mode and their low detection limits. However, working in MS-MS mode makes any MS system blind to other compounds of interest.
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Ion Chromatography–Mass Spectrometry for Profiling Low Molecular Mass Organic Acids in Beverages and BiomassThis article describes an ion chromatography–mass spectrometry (IC-MS) method for profiling low molecular mass organic acids in consumer beverages and biomass used in biofuel production.
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Accelerated Discovery and Quantitation of Lipids in Complex ExtractsThe authors discuss analytical methods for lipidomics.
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Accelerated Discovery and Quantitation of Lipids in Complex ExtractsThe authors discuss analytical methods for lipidomics.
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Peptide Mapping of Monoclonal Antibodies and Antibody–Drug Conjugates Using Micro-Pillar Array Columns Combined with Mass SpectrometryThe structural complexity of monoclonal antibodies (mAbs) challenges the capabilities of even the most advanced chromatography and mass spectrometry techniques. This study examines the use of micro-pillar array columns in combination with mass spectrometry for peptide mapping of both mAbs and antibody–drug conjugates (ADCs).
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Application of Unique Software Tools Dedicated to Multiline Analysis by CCD-Based ICP-AES for Geological SamplesMultiline analysis, which consists of using several lines per element to detect positive or negative bias caused by spectral interferences, is an ideal way to use all the information emitted by the plasma and collected by a charge-coupled device detector. However, method development and validation become more complex. Dedicated software has been developed to overcome it, and analysis of geological samples will illustrate their benefit in achieving high reliability of results.
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ICP-MS: A Universally Sensitive GC Detection Method for Specialty and Electronic Gas AnalysisThe authors discuss the use of ICP-MS as an effective chromatographic detection method that is relatively easy to interface to gas chromatography for gas analysis.
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Spatial Resolution in IR Reflectance Imaging — NIR, Mid-IR, and ATRWhen images are measured in reflectance, the observed structure is not necessarily just that of the sample surface.
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A Sensitive, Specific, Accurate, and Fast LC–MS-MS Method for Measurement of 42 Ethyl Glucuronide and Ethyl Sulfate in Human UrineA method is illustrated for the simultaneous analysis of ethyl glucuronide and ethyl sulfate in human urine samples.
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Ultratrace Aluminum Analysis of Nutritional Intravenous Solution Components in 1-Propanol Using GFAAS (PDF)This article describes how ultratrace aluminum analysis of two nutritional intravenous solution components with limited water solubility can be performed by graphite furnace atomic absorption spectroscopy (GFAAS) with dissolution in 1-propanol.
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Analysis of Small Molecules with amaZon: Enhanced Sensitivity, Speed, and Dynamic RangeThe amaZon series is the next step in Bruker Daltonics' family of ion trap mass spectrometers.
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A Simplified Approach to Optimize SPE Method Development with Downstream LC–MS Analysis Allowing 100% Organic, Basified Injection SolventsHere, the authors demonstrate the use of a systematized approach to SPE method development and LC–MS-MS analysis.
