A New Mass Spectrometry Method for Analyzing Complex Samples

A pioneer of FT-ICR Mass Spectrometry, Alan G. Marshall (1944–2025), is best known for co-inventing Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS), a transformative technique that enabled ultrahigh-resolution analysis of complex mixtures. Over a career spanning more than five decades at institutions like the University of British Columbia, The Ohio State University, and Florida State University, he published over 650 peer-reviewed papers and mentored more than 150 scientists. Marshall’s work profoundly impacted fields ranging from astrobiology to petroleomics and earned him numerous prestigious awards and fellowships. Revered for his intellect, mentorship, and dedication to science, he leaves behind a legacy that continues to shape modern mass spectrometry.

An interview with Charles Wilkins, the winner of the 2013 American Chemical Society Division of Analytical Chemistry Award in Chemical Instrumentation, sponsored by the Dow Chemical Company.

In this extended Q&A interview, we sit down with Kelsey Williams, a postdoctoral researcher at Los Alamos National Laboratory (LANL), who is working on planetary instrumentation using spectroscopic techniques such as laser-induced breakdown spectroscopy (LIBS) and laser ablation molecular isotopic spectrometry (LAMIS). In Part III, Williams goes into detail about ChemCam and SuperCam and how LIBS is used in both these instruments.

In this extended Q&A interview, we sit down with Kelsey Williams, a postdoctoral researcher at Los Alamos National Laboratory (LANL), who is working on planetary instrumentation using spectroscopic techniques such as laser-induced breakdown spectroscopy (LIBS) and laser ablation molecular isotopic spectrometry (LAMIS). In Part II of our conversation with Williams, she talks about the potential of mass spectrometry (MS) in space exploration applications.

In honor of National Space Day, we interviewed Kelsey Williams, who is a postdoctoral researcher at Los Alamos National Laboratory (LANL) working on planetary instrumentation using spectroscopic techniques such as laser-induced breakdown spectroscopy (LIBS) and laser ablation molecular isotopic spectrometry (LAMIS). In Part I of our interview with Williams, she discusses how her background led her to her current position at LANL.

Scientists at Oak Ridge National Laboratory have demonstrated that a fast, laser-based mass spectrometry method—LA-ICP-TOF-MS—can accurately detect and identify airborne environmental particles, including toxic metal particles like ruthenium, without the need for complex sample preparation. The work offers a breakthrough in rapid, high-resolution analysis of environmental pollutants.