In the first part of this three-part interview, Ayanjeet Ghosh of the University of Alabama and Rohit Bhargava of the University of Illinois Urbana-Champaign discuss their interest in using discrete frequency infrared (IR) imaging to analyze protein secondary structures.

Top articles published this week include a new Icons of Spectroscopy column, a news story about the use of Fourier transform infrared (FT-IR) spectroscopy in gemology, and a Q&A interview about elemental analysis in pharmaceutical analysis.

In this final part of our conversation with Harrington and Seibert, they discuss the main challenges that they encountered in their study and how we can improve elemental impurity analysis in pharmaceutical quality control.

Researchers from Jiangnan University introduced a sensitive, selective, and highly adaptable new probe for detecting hydrazine.

Researchers at the Sinopec Research Institute have developed a novel method using virtually generated mid-infrared spectra to accurately quantify plastic blends, offering a faster, scalable solution for recycling and environmental monitoring.

In Part II of our conversation with James Harrington of RTI International in Research Triangle Park, North Carolina, who was the lead author of this study, as well as coauthor Donna Seibert of Kalamazoo, Michigan, they talk about the reproducibility for Hg and V, as well as the ICP-MS and XRF results compare to one another.

Scientists at the University of Barcelona have developed a fast and reliable way to identify natural, treated, and synthetic rubies and sapphires using Fourier-transform infrared (FT-IR) spectroscopy. Their study reveals unique spectral fingerprints for different gemstone types, offering a powerful tool in the fight against gem fraud.

Spectroscopy sat down with James Harrington of Research Triangle Institute (RTI International) in Research Triangle Park, North Carolina, who was the lead author of this study, as well as coauthor Donna Seibert of Kalamazoo, Michigan. In Part I of our conversation with Harrington and Seibert, they discuss the impact of ICH Q3D and United States Pharmacopeia (USP) <232>/<233> guidelines on elemental impurity analysis and how they designed their study.

Our “Chemometrics in Spectroscopy” column highlights the methodology that is used in order to apply chemometric methods to data. Integrating chemometrics with spectroscopy allows scientists to understand solutions to their problems when they encounter surprising results. Recently, columnists Howard Mark and Jerome Workman, Jr., wrote a series of articles about data transforms in chemometric calibrations. In this listicle, we profile all pieces in this series and invite you to learn more about applying chemometric models to continuous spectral data.

A recent astronomical study saw a research team from Argentina study an open star cluster using spectroscopy instrumentation.

A historical and technical overview from the Gemological Institute of America (GIA) explores how advanced scientific instruments—particularly spectroscopic methods—have transformed gem identification. From refractometers to modern spectrophotometers, this deep dive highlights the evolving challenges and solutions in gem testing.

A new study in the Journal of Food Composition and Analysis showcases high-performance detection using artificial intelligence and spectroscopy.

Researchers at Harbin Medical University recently developed a SERS-based diagnostic platform that uses DNA-driven “molecular hooks” and AI analysis to enable real-time detection of cardiovascular drugs in blood while eliminating interference from larger biomolecules.

New research from the Gemological Institute of America highlights the essential role of infrared spectroscopy in identifying gemstones, detecting treatments, and distinguishing natural from synthetic gems. The technique’s precision and non-destructive nature have made it an indispensable tool in modern gemology.

Researchers in South Korea demonstrate a fast and reliable method for measuring lithium isotope abundance using dual-laser plasma technology.