Improving Drug Formulation with Raman and IR Spectroscopy
The physicochemical properties of drugs are often very diverse and challenging to analyze. Spectroscopy recently spoke with Dr. Lynne Taylor of the Department of Industrial and Physical Pharmacy at Purdue University, and the 2014 Coblentz Society Craver Award winner, about her on-going research using Raman and IR spectroscopy to study drugs and drug excipients — and the interactions of the two. Here, she discusses the various avenues of her research, including crystallization and drug-rich nanodroplets.
A New Mass Spectrometry Method for Analyzing Complex Samples
This interview with Steven J. Ray, an Associate Scientist in the Department of Chemistry at Indiana University in Bloomington, Indiana, discusses his work with a new form of mass spectrometry (MS) for analyzing complex samples. Ray's research focuses on time- and polarization-dependent fluorescence spectroscopy, novel sources for atomic emission and atomic and ambient mass spectrometry, various sample introduction systems, and most recently, time-of-flight mass spectrometers for plasma-source and biomolecular MS. He has been selected to receive the 2014 Lester W. Strock Award, which is being given in recognition of a seminal paper (published in 2011) that reduced to practice the technique of distance-of-flight (DOF) MS.
Seeing Things That Have Never Been Observed Before: Pushing the Limits of Mass Spectrometry
Mass spectrometry is a powerful analytical tool. Yet researchers and instrument makers continue to push the limits of its resolving power. One such researcher is David E. Clemmer, the Robert & Marjorie Mann Chair and Distinguished Professor of Chemistry at Indiana University in Bloomington, Indiana and the 2014 Anachem Award winner. Clemmer's group has done extensive research to develop and improve ion trapping techniques and ion mobility spectrometry-mass spectrometry (IMS-MS) instruments to analyze biomolecular mixtures and structures. Spectroscopy recently spoke with Clemmer about this work.
Surface-Enhanced Raman Spectroscopy: Fundamental Research and Practical Applications
Surface-enhanced Raman spectroscopy (SERS) enhances the Raman signal using molecules adsorbed on rough metal surfaces. This interview with 2014 Charles Mann Award winner Richard P. Van Duyne of Northwestern University discusses his group's work with tip-enhanced Raman spectroscopy, single-molecule SERS, a SERS system for glucose analysis, and SERS as a method for analyzing colorants in artworks.
Understanding Biological Systems at the Quantum Level Using 2D Electronic Spectroscopy
Spectroscopy recently spoke to Greg S. Engel, who is an Associate Professor in the Department of Chemistry at the University of Chicago in Chicago, Illinois, and one of the winners of the 2013 FACSS Innovation Awards. Here, Engel discusses his research examining quantum dynamics in biology, chirality in dynamics, and the use of two-dimensional electronic spectroscopy.
Putting a Spectrometer on a Cell Phone
Will your next cell phone include a spectrometer? In this interview, Alexander Scheeline talks about what is involved in creating such a device, and his work toward that end. This interview is part of Spectroscopy's 2014 interview series with the winners of awards that are presented at the SciX conference.
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