April 12th 2024
Here are the top five articles that the editors of Spectroscopy published this week.
TLC-MALDI in Pharmaceutical Analysis (PDF)
April 29th 2004Thin-layer chromatography (TLC) is a widely used technique for the rapid examination of compound purity. The amount of qualitative information, however, is limited to the retention factor of compounds. The technique described here enables the direct determination of TLC plates by MALDI MS.
Versatile Protein Identification Using AP-MALDI Ion Trap Mass Spectrometry (PDF)
April 29th 2004New developments in matrix-assisted laser desorption ionization (MALDI) technology enable decoupling of the ionization source from the time-of-flight mass analyzer for operation at atmospheric pressure (AP-MALDI). This technique also can be integrated with other types of mass analyzers, such as the ion trap.
Tautomerism and Expert Systems in Spectroscopy (PDF)
April 1st 2004Because tautomers often cannot be isolated as single isomers, spectroscopists should always anticipate possible tatomeric forms that can complicate the interpretation of their spectra. This involves the use of spectral databases and tautomerically enabled search algorithms.
The authors discuss progress in near-field IR microspectroscopy using a photothermal probe and show how it can be applied to the spectroscopic characterization of real-world samples.
The authors discuss progress in near-field IR microspectroscopy using a photothermal probe and show how it can be applied to the spectroscopic characterization of real-world samples.
Source Design and the Utility of Multimode Ionization (PDF)
January 1st 2004The author discusses how the physical realm of the atmospheric ionization source -- materials, gas, and heat dynamics -- and manipulating the ionization modes themselves perhaps are the current forefront of technological innovation.