Analytical Tools for the Characterization of Biopharmaceuticals: Mass Spectrometric Detection

November 1, 2014
Sarah Cianferani

Spectroscopy E-Books

Spectroscopy E-Books, Spectroscopy E-Books-11-01-2014, Volume e2, Issue 3

A complete set of mass spectrometry tools is available for mAb characterization, and includes bottom-up approaches, middle-up analysis of mAb fragments, and intact mAb analysis. In some cases, these tools are being coupled with chromatographic separation methods while in others they are being used with innovative techniques such as native MS and native ion mobility mass analysis. In particular, native MS techniques can play a key role in the characterization of higher-order structures.   Read more