Infrared (IR) Spectroscopy

Should the Past Define the Future of Interpretation of Infrared and Raman Spectra?

June 01, 2020

Spectroscopy

In celebration of Spectroscopy’s 35th Anniversary, leading spectroscopists discuss important issues and challenges in analytical spectroscopy.

Analysis of FDA Infrared 483 Citations: Have You a Data Integrity Problem?

September 01, 2019

Spectroscopy

Analysis of FDA Form 483 observations and warning letters for infrared spectrometers reveals a range of data integrity problems and a lack of laboratory procedures for the technique. Is your laboratory in the same situation?

Organic Nitrogen Compounds V: Amine Salts

September 01, 2019

Spectroscopy

The amine salt functional group contains ionic bonding, and is extremely polar, giving rise to a number of intense and uniquely placed peaks that are easy to identify for primary, secondary, and ter tiary amines.

Advancing Biomedical Research with New Infrared and Raman Microscopy Techniques

June 10, 2019

Spectroscopy

Significant progress is being made to harness the power of spectroscopy technique for medical research. An ongoing challenge, and area of development, in this effort, is to “see” more and more detail about biological activity, even within individual cells. Ji-Xin Cheng, a professor of biomedical engineering at Boston University, is advancing such work, by developing techniques like midinfrared photothermal (MIP) imaging and Raman spectromicroscopy. Cheng is the 2019 winner of the Ellis R. Lippincott Award, which is awarded annually by the Optical Society, the Coblentz Society, and the Society for Applied Spectroscopy, to an individual who has made significant contributions to the field of vibrational spectroscopy. Here, Cheng speaks to us about those techniques.

Review of New Spectroscopic Instrumentation 2019

May 01, 2019

Spectroscopy

Our annual review of products introduced at Pittcon or during the previous year

Organic Nitrogen Compounds III: Secondary and Tertiary Amines

May 01, 2019

Spectroscopy

A detailed guide to interpreting the infrared spectra of organic nitrogen compounds, including secondary and tertiary amines.

The Use of Portable Near-Infrared Spectroscopy for Authenticating Cardiovascular Medicines

May 01, 2019

Spectroscopy

Portable NIR spectroscopy is demonstrated as a rapid and mobile analysis method for authenticating cardiovascular medicines in critical situations, and to indicate whether formulations are counterfeit or substandard.

The C=O Bond, Part VII: Aromatic Esters, Organic Carbonates, and More of the Rule of Three

September 01, 2018

Spectroscopy

Aromatic esters follow the ester Rule of Three, but each of these three peak positions is different for saturated and aromatic esters, which makes them easy to distinguish. Organic carbonates are structurally similar to esters and follow their own Rule of Three.

The C=O Bond, Part VI: Esters and the Rule of Three

July 01, 2018

Spectroscopy

Esters are a common and economically important functional group made by reacting an alcohol and a carboxylic acid.

The Carbonyl Group, Part V: Carboxylates—Coming Clean

May 01, 2018

Spectroscopy

Carboxylates are made by reacting carboxylic acids with strong bases such as inorganic hydroxides. Carboxylates contain two unique carbon–oxygen “bond and half” linkages that coordinate with a metal ion to give two strong infrared peaks, which make them easy to see.