Pharmaceutical Analysis

Using XRF as an Alternative Technique to Plasma Spectrochemistry for the New USP and ICH Directives on Elemental Impurities in Pharmaceutical Materials

July 01, 2017

Spectroscopy

An evaluation of the ability of XRF spectrometry to perform elemental impurity analysis of 12 elements in various pharmaceutical materials

Supplementary Information: Using XRF as an Alternative Technique to Plasma Spectrochemistry for the New USP and ICH Directives on Elemental Impurities in Pharmaceutical Materials

June 28, 2017

These tables are supplementary to the “Atomic Perspectives” column installment “Using XRF as an Alternative Technique to Plasma Spectrochemistry for the New USP and ICH Directives on Elemental Impurities in Pharmaceutical Materials,” which was published in the July 2017 issue of Spectroscopy (1).

Solvent Assisted Ionization Mass Spectrometry for Screening and Quantification of Counterfeit Drugs

July 01, 2015

Special Issues

Because of the wide variety of ways counter drugs have been entering the pharmaceutical supply chain, there is an imminent need for quick and inexpensive methods to identify drug components and quantify active ingredients. Here, we report results illustrating the screening properties of solvent assisted ionization mass spectrometry (SAI-MS) and the quantitative properties of liquid chromatography (LC)-SAI-MS. These methods offer high sensitivity, versatility, and in combination, rapid turnaround time. Suspect samples of fexofenadine hydrochloride and hydroxychloroquine were rapidly screened and compared to their legal counterparts using SAI-MS.

What's New in Testing Pharmaceuticals for Metals: Metals and Limits in Limbo

May 01, 2014

Spectroscopy

This article covers the changes so far to United States Pharmacopeia (USP) chapters and , the International Conference on Harmonisation (ICH), the European Medicines Agency (EMA), and the European Pharmacopoeia (EP), impending changes, and options for preparing for those changes.

Bioprocess Monitoring with Ultrasound-Enhanced ATR Mid-IR Spectroscopy

June 18, 2012

Spectroscopy

Bernhard Lendl and Cosima Koch of the Vienna University of Technology have developed a new method for on-line monitoring of fermentations using mid-infrared spectroscopy.

Detection and Sourcing of Counterfeit Pharmaceutical Products and Consumer Goods

August 01, 2009

Special Issues

The authors discuss the use of vibrational spectroscopy to differentiate an authentic article from a counterfeit one throughout a product's lifecycle, from component receipt at the site of manufacture, to product receipt by the end user.

Rapid Identification of Illicit and Prescription Drugs Using FT-NIR Spectroscopy

August 01, 2008

Special Issues

The authors discuss the use of FT-NIR to identify several different types of drug formulations.

Synthesis and Structural Elucidation of Impurities in Ramipril Tablets

July 01, 2008

Special Issues

In this article, the authors take a look at the identification, synthesis, and characterization of impurities in Ramipril tablets.

Dosing Vehicle Removal in Discovery Phase Pharmacokinetic Studies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry

July 01, 2008

Special Issues

This article describes the ability to increase the sensitivity for a target compound in the presence of high-level background impurities by removing the dosing vehicle using a high-field asymmetric waveform ion mobility spectrometry gas-phase separation before mass spectrometry analysis.

ICP-MS Speciation Analysis: Three Roles of Selenium

February 01, 2006

Spectroscopy

The element selenium plays three distinct roles in biological processes, functioning in turn as a toxicant, a chemopreventive agent, and a heavy metal antagonist. This article discusses current research associated with each role, and how ICP-MS can be employed to better understand and utilize selenium's properties.