Biological, Medical, and Clinical Analysis

New Spectroscopy-Based Approaches in Bioanalysis and Personalized Medicine

December 01, 2017


Medical diagnostics is an exciting area of spectroscopy research, and one of the dreams is to develop spectroscopic tools that can be used for point-of-care diagnostics with a smartphone. Russ Algar, the 2017 Emerging Leader in Molecular Spectroscopy, is one of the scientists on that quest

High Spatial Resolution FT-IR Imaging of Biomedical Tissue Samples Using Existing Objectives

April 22, 2015


Fourier Transform Infrared (FTIR) imaging is a well-established analytical method for obtaining spectral and spatial information simultaneously in the micron-size domain. The technique has been applied across many different application areas, from polymer science to biomedical imaging. Over recent years, interest has increased in pushing the diffraction limited spatial resolution performance of FTIR imaging systems, primarily using synchrotron based systems.

Optimizing Tissue Preparation and Storage for Analysis of Polyunsaturated Fatty Acids Using Agilent’s FT-IR Imaging Systems

April 22, 2015


Mammals require dietary-based polyunsaturated fatty acids (PUFA) such as docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA) for many biological processes, including normal functioning of the retina and brain. Fourier transform infrared (FTIR) imaging with high spatial resolution is a suitable tool to investigate the PUFA distribution in tissue sections from animal models of disease, providing comprehensive information of the biochemical components on the subcellular scale.

FT-IR Microscopic Imaging of Large Samples with 4x and 15x Infrared Objectives: A Case Study of a Carcinoma Tissue Section

April 22, 2015


Fourier transform infrared (FTIR) microscopic imaging uses a combination of an FTIR spectrometer with a microscope and Focal Plane Array (FPA) detector. The method has been recognized as a powerful and versatile imaging tool in many disciplines, ranging from biomedical research through to materials science, art conservation and forensics.

Duncan Graham Named Recipient of Coblentz Society's 2012 Craver Award

February 22, 2012

The Coblentz Society and the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) recently named Professor Duncan Graham of the University of Strathclyde (Glasgow, Scotland) as the recipient of the Coblentz Society?s 2012 Craver Award.

Special Issues

FT-IR–Raman Combination: The Perfect Analytical Solution for Vibrational Spectroscopists

August 01, 2009

The authors discuss the combined use of Raman and FT-IR spectroscopy in fields such as forensic science, biomedical science, catalysis, and polymers.

New Technique for Detection of Carbon Nanotubes in the Body

May 14, 2009

New research being conducted at the University of Arkansas is demonstrating that Raman spectroscopy can be used to detect and monitor circulating carbon nanotubes in vivo and in real time.

Mass Spectrometry and Glial Cells

April 20, 2009

Using a new mass spectrometry technique and stem cells that can be made to produce either neurons or glial cells, a team of researchers at the Salk Institute for Biological Studies (La Jolla, California) identified a molecular signaling pathway that is required for the production of glial cells, yielding insight into the neurobiology of Down?s syndrome and several nervous system disorders characterized by too many glial cells.


Miniature Optical Spectrometers: Follow the Money Part II: The Telecommunications Boom

February 01, 2008

The author examines NIR spectrometers and the technologies developed during the telecommunications boom of the late 1990s, focusing on miniaturized optical techniques generally called MOEMS.


Probing the Structural Effects of Pasteurization and Spray Drying on Soy Protein Isolate in the Presence of Trehalose Using FT-IR-ATR and FT-Raman Spectroscopy

May 01, 2007

The authors present the results of a study in which FT-IR-ATR and FT-Raman spectrosopies were used to probe the effects of pasteurization and spray drying on the secondary structure of soy protein isolate.