Liquid chromatography coupled with high-resolution mass spectrometry (LC–HRMS) is used in combination with a comprehensive data analysis workflow to screen water samples for potentially hazardous transformation products from organic micropollutants to determine the efficacy of different water treatment methods.
When explosives are encountered on the battlefield, the use of portable GC–MS is valuable for the detection and confirmatory identification of pre- and post-detonation threats. In addition, this technique provides information about the source of explosives based on the detection and identification of trace-level chemicals in the sample. The data presented here confirm this capability.
Size-exclusion chromatography (SEC), with the use of ammonium acetate buffer, can be coupled on-line to electrospray ionization MS for the characterization of size variants of therapeutic monoclonal antibodies (mAbs). A quadrupole time-of-flight (QTOF) MS system was employed, and the MS method was optimized to achieve favorable sensitivity for high-mass detection, while maintaining the structural integrity of the aggregates (or high molecular weight species) and fragments (or low molecular weight species).
Per- and polyfluoroalkyl substances (PFAS) are found in firefighting foams and consumer products. They are ubiquitous in the
environment and are an emerging human health concern. This work compares the 2009 and 2018 revised US Environmental
Protection Agency (EPA) LC–MS/MS methods of analysis for PFAS in drinking water.
In the human food supply, public confidence is affected by contaminants and misreporting of nutritional information. This article
highlights three events that required development of new mass spectrometry methods, including the detection of pesticides (such as fipronil and glyphosate), and the detection and quantification of fat-soluble vitamins.
In late-stage pharmaceutical development a new generation of high-resolution mass spectrometers and ion mobility mass
spectrometers operate as orthogonal separation techniques and have greatly increased the ability to resolve impurities and increase the level of analytical information gained from a single analysis.
In this study, atmospheric pressure photoionization (APPI) is compared to the default ionization method, electrospray ionization (ESI), for solution-phase samples. These mass spectrometry methods are compared and optimized relative to artificial wastewater for the detection and quantitation of pharmaceuticals frequently found as environmental contaminants.