Appendix IV: Mass spectrometry
Appendix IV: Mass spectrometry
Manufacturer: Hiden Analytical Ltd
Product name: QGA Atmospheric Gas Analysis System
Mass spectrometer
New this year: The new Hiden QGA Professional gas/vapor analysis software
Used for: Lab applications
Software: QGA Professional / MASsoft 7 Professional; may be used in other equipment, compatible with other manufacturers' equipment
Special features: Provides real-time continuous and quantitative analysis of gas mixtures comprising up to 16 species and is now available for operation with all Hiden gas analysis systems.
Suggested applications: High purity gas analysis, fermentation, fuel cells, gas production and storage, environmental monitoring
Primary benefits: Appearance potential mass spectrometry, fast response times – less than 300 ms, acquisition speed up to 500 measurements/s, Hiden QIC (quartz inert capillary) sampling interface samples from 100 mbar to 2 bar
Manufacturer: Markes International Ltd.
Product name: Select-eV
Mass spectrometer
New this year: New variable-energy electron ionization for GC–MS
Special features: No loss in sensitivity for fast and accurate compound identification
Used for: Lab analysis
Unique features: Source can change the energy of ionizing electrons; this allows the production of reference-quality electron ionization mass spectra with conventional full-fragmentation patterns. Energies can be varied anywhere from standard 70 eV down to 10 eV without loss in sensitivity; sometimes signal-to-noise ratios of many compounds are increased at lower energies.
Manufacturer: Microsaic Systems plc
Product name: 4000 MiD
Portable mass spectrometer
Used for: Lab, process, handheld analysis
Dimensions: 55 x 35 x 25 cm; weight: 32 kg
Measurement mode: Full scan (m/z 50-800), SIM and simultaneous SIM/fullscan
Software: Masscape, available as separate product, may be used in other equipment, compatible with other manufacturers' equipment.
Suggested applications: Mass detection for use in prep-, analytical-, flash- LC, reaction monitoring, flow chemistry, batch reaction online analysis, process monitoring.
Primary benefits: Deployability, everything fits inside a lab fume hood. You can take the mass spectrometer to the point of need.
Unique features: Smallest footprint single quadrupole MS, uses technology based on MEMS manufacturing, Fits in a standard fume hood, No external roughing pump needed, Integrated PC, remote operation supported, No A/C or sound-proofing required; deployability in a lab.
Manufacturer: Shimadzu
Product name: LCMS-8050
Triple-quadrupole LC–MS-MS system
New this year: Multiple reaction monitoring, 5-ms polarity switching, quantitative and qualitative analysis of multiple components.
Used for: Lab analysis
Primary benefits: 5 ms polarity switching, scan rate of 30,000 u/s, 555 MRM/s, heated ESI probe, high-efficiency CID cell maintains signal intensity
Unique features: Data browser and an automated MRM optimization routine. Application-specific method packages.
Manufacturer: Waters Corporation
Product name: Waters ionKey/MS System
Mass spectrometer
Used for: Lab analysis
Measurement mode: Microfluidic device and source for mass spectrometry.
Software: Available as separate product, 21CFR11 compliant, cGMP compliant, may be used in other equipment, compatible with other manufacturers' equipment
Suggested applications: Bioanalyses, pharmacokinetic studies, food safety and environmental analyses
Primary benefits: Enhanced sensitivity, plug and play nature: the Waters iKey separation device is designed so that all it takes is a few seconds for a scientist to insert it into the source of the mass spectrometer and with the turn of a key, make the fluidic and electric connections and lock it into place.
Unique features: The ionKey/MS System's iKey microfluidic separation device contains the fluidic connections, electronics, ESI interface, column heater, eCord Intelligent Chip technology and the 1.7-μm UPLC-grade particles packed inside a 150-μm i.d. channel. Stores the iKey device's dimensions, chemistry type, serial no., manufacturing and QC history on a unique eCord chip. Waters is offering several 1.7-μm UPLC grade particles for the ionKey/MS system available in 5 cm and 10 cm pathlengths: C18 BEH (Bridged Ethyl Hybrid) 300 Å, CSH (Charged Surface Hybrid), C18 BEH 130 Å
AI and Dual-Sensor Spectroscopy Supercharge Antibiotic Fermentation
June 30th 2025Researchers from Chinese universities have developed an AI-powered platform that combines near-infrared (NIR) and Raman spectroscopy for real-time monitoring and control of antibiotic production, boosting efficiency by over 30%.
Toward a Generalizable Model of Diffuse Reflectance in Particulate Systems
June 30th 2025This tutorial examines the modeling of diffuse reflectance (DR) in complex particulate samples, such as powders and granular solids. Traditional theoretical frameworks like empirical absorbance, Kubelka-Munk, radiative transfer theory (RTT), and the Hapke model are presented in standard and matrix notation where applicable. Their advantages and limitations are highlighted, particularly for heterogeneous particle size distributions and real-world variations in the optical properties of particulate samples. Hybrid and emerging computational strategies, including Monte Carlo methods, full-wave numerical solvers, and machine learning (ML) models, are evaluated for their potential to produce more generalizable prediction models.
