Fourier Transform Infrared (FTIR) imaging is a well-established analytical method for obtaining spectral and spatial information simultaneously in the micron-size domain. The technique has been applied across many different application areas, from polymer science to biomedical imaging. Over recent years, interest has increased in pushing the diffraction limited spatial resolution performance of FTIR imaging systems, primarily using synchrotron based systems.
Jürgen Popp, winner of this year’s Ellis R. Lippincott Award, discusses the regulatory, cost, and workflow hurdles of moving Raman spectroscopy into hospitals.
Microspectroscopy, the marriage of spectroscopic chemical identification with microscopic spatial resolution, has advanced from Perkin-Elmer's first commercial infrared microspectrometer in 1953 to today's nanoscale AFM-IR probes, synchrotron-brightness infrared beamlines, and compact hyperspectral tissue imaging devices being developed for AI-assisted cancer detection.
Atomic spectroscopy has quietly gone from counting elements in bulk to counting single nanoparticles, imaging tissue at the micrometer scale, and reading Martian rocks from several meters away. The instruments got smaller, the software got smarter, and the questions they can now answer got a lot more interesting.
UV–vis absorption spectroscopy, one of analytical chemistry's oldest and most accessible techniques, remains foundational to cutting-edge science, underpinning the Nobel Prize-winning discovery and synthesis of quantum dots and continuing to evolve through ultralow stray-light optics, chip-scale sensors, and AI-integrated process analyzers.
In this interview segment from SciX, Juergen Popp explains why molecular “twins” built from optical measurements could reach patients within a decade, provided the field builds the regulatory, computing, and standards ecosystem around the technology.
At SciX, Jürgen Popp explains how miniaturized optical spectroscopy could add molecular data to wearable health tracking, which could enable earlier disease detection and a shift toward prevention.
At SciX, Jay Kitt describes the experiment he ran on his own that launched his cytochrome c research, and explains why putting a number on peptide–lipid interactions matters.