Metrohm's Raman Spectrometers

Researchers at Budapest University of Technology and Economics have developed a novel method for real-time monitoring of the protein purification process using Raman and near-infrared (NIR) spectroscopy. Their study compares the effectiveness of these two spectroscopic techniques in tracking the removal of imidazole, a process-related impurity, during the purification of the SARS-CoV-2 spike protein's receptor-binding domain (RBD).

Researchers from Humboldt-Universität zu Berlin and the German Aerospace Center (DLR) have developed a cutting-edge fiber-dispersive Raman spectrometer (FDRS) capable of detecting low-density biological matter in space. By combining a single-photon detector with a dispersive optical fiber element, the team achieved a breakthrough in in-situ Raman spectroscopy, promising unprecedented sensitivity and reliability in the search for extraterrestrial rudimentary life.

A recent study explores the strengths and limitations of spatially offset Raman spectroscopy (SORS) and micro-SORS, offering new insights into their applications for non-invasive subsurface material analysis. The findings provide valuable guidelines for choosing between these techniques based on sample characteristics and analytical needs.

An innovative study has demonstrated that two-dimensional correlation spectroscopy (2D-COS) can effectively differentiate between toxic and biocompatible carbon nanofibers (CNFs), offering a novel method for evaluating the safety of nanomaterials intended for medical use.

Recent advancements in highly-multiplexed Raman imaging are set to revolutionize 3D spatial biology, offering unprecedented insights into complex biological systems. This new technology, highlighted in the Royal Society of Chemistry journal Chemical Communications, was reported by researchers from Shanghai Medical College, shows promise for enhancing our understanding of physiological functions and disease progression.

Surface-enhanced Raman spectroscopy (SERS) is emerging as a powerful tool in brain research, offering enhanced sensitivity and stability over traditional methods. This technique promises to revolutionize the diagnosis and understanding of brain disorders, such as Alzheimer's and Parkinson's diseases, by providing rapid, reliable, and non-invasive diagnostic capabilities.