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Latest:
The Use of Portable Near-Infrared Spectroscopy for Authenticating Cardiovascular MedicinesPortable NIR spectroscopy is demonstrated as a rapid and mobile analysis method for authenticating cardiovascular medicines in critical situations, and to indicate whether formulations are counterfeit or substandard.
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A Different Kind of Art AnalysisRaman and XRF spectroscopy were used to examine paint in artwork, revealing the potential of both techniques to verify the authenticity of famous works of art.
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Non-Destructive Red Wine Measurement with Dispersive 1064 nm Raman SpectroscopyOwing to technological improvements spurred on by the telecommunications boom of the last decade, Raman spectroscopy has become much more accessible to users in all application areas, including agricultural, forensic, pharmaceutical, biomedical, and others.
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A Novel Approach to Measure Crop Plant Protein ExpressionCrop development to improve yield or disease resistance has been explored for centuries and the technologies to measure these improvements have subsequently become complex. The use of transgenes in crop plants is a more technically advanced approach than traditional breeding and the success of this approach is best assessed using modern techniques that accurately quantify the desired traits. Here, we applied targeted liquid chromatography–mass spectrometry (LC–MS) using synthetic stable isotope–labeled peptides to identify and quantify the relative levels of transgenic to native protein.
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Polar Vapor-Enhanced Separations with Planar Differential Mobility Spectrometry-Mass SpectrometryA brief historical overview of DMS, followed by a synopsis of the instrumentation, physics, and chemistry behind the separation principles
Latest:
A Novel Approach to Measure Crop Plant Protein ExpressionCrop development to improve yield or disease resistance has been explored for centuries and the technologies to measure these improvements have subsequently become complex. The use of transgenes in crop plants is a more technically advanced approach than traditional breeding and the success of this approach is best assessed using modern techniques that accurately quantify the desired traits. Here, we applied targeted liquid chromatography–mass spectrometry (LC–MS) using synthetic stable isotope–labeled peptides to identify and quantify the relative levels of transgenic to native protein.
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The Use of Mass-Spectrometry-Based Proteomics for Reliable Detection and Identification of Pathogens as Illustrated by the Study of Bee Colony Collapse DisorderA study of colony collapse disorder in honey bees illustrates how mass spectrometry–based proteomics techniques can be used to to identify pathogens without any prior knowledge of what is contained in the sample.
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Toward Quantitative Imaging Mass SpectrometryThe main limitations of quantification using MALDI imaging are discussed and the different approaches used for quantitative measurement in MSI are evaluated.
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Low Temperature Analysis of Kaolin Clay Using Diffuse ReflectanceClays, like kaolinite and smectite, are hygroscopic and it is well known that the adsorbed water can be driven off at elevated temperatures. At very low temperatures, in addition to the typical band narrowing and shifting, changes in the O-H bond vibrational modes of clays have also been observed.
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Identification of Novel Psychoactive Substances Using Hyphenated Mass Spectrometric TechniquesGas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS) techniques offer advantages in separating and confirming the identity of constituents in novel psychoactive substances.
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Versatile Protein Identification Using AP-MALDI Ion Trap Mass Spectrometry (PDF)New developments in matrix-assisted laser desorption ionization (MALDI) technology enable decoupling of the ionization source from the time-of-flight mass analyzer for operation at atmospheric pressure (AP-MALDI). This technique also can be integrated with other types of mass analyzers, such as the ion trap.
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Nontargeted, Discovery-Based Profiling of the Yeast Metabolome Using QTOF LC–MS and LC–MS-MSA discovery-based, untargeted metabolomics analysis of hundreds of yeast metabolites under robust, controlled extraction conditions followed by identification is described.
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Macro ATR-FT-IR Spectroscopic Imaging of Dynamic ProcessesMacro attenuated total reflection FT-IR spectroscopic imaging is a powerful and underutilized tool. This article presents an overview of approaches and opportunities for using this method to study dynamic processes such as diffusion, sorption, crystallization, and dissolution.
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Fast Multidimensional NMR Spectroscopy by the Projection-Reconstruction Technique (PDF)The authors describe a new method for making faster measurements of multidimensional NMR spectra. The technique involves acquiring a small number of projections and using them to reconstruct the entire spectrum.
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Enhancing Trace Element Analysis with Inductively Coupled Plasma Mass SpectrometryElemental analysis is crucial in a wide variety of applications from detecting toxic elements within the environment, to ensuring drinking water is safe for human consumption, to food product safety. ICP-MS—able to measure an atom’s mass—offers low detection limits in the range of parts per trillion (ppt), making it a widely used method that can detect toxic elements well below regulatory limits. This paper expands upon how new ICP-MS technology can meet the challenges associated with heightened demands for element analysis and the hurdles laboratories face when analyzing high-matrix samples.
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High Resolution 1H NMR Spectroscopy of Metabolically Active Microorganisms Using Non-Destructive Magic Angle Spinning (PDF)The authors show that high resolution 1H nuclear magnetic resonance (NMR) spectroscopy can be used to study biofilm metabolism under environmentally relevant conditions in a minimally invasive way.
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Metabolomics in Food and Nutrition LaboratoriesA look at the various strategies and tools related to metabolomics applied to food and nutrition.
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Raman spectroscopy applied to art, archaeology and earth sciencesIR and Raman spectroscopy are powerful analytical techniques to detect, discriminate and identify material on a molecular level. In particular Raman spectroscopy offers some advantages when applied to art and archaeology as well as earth sciences.
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Performance Characterization of ion Detectors in Harsh EnvironmentsRecent developments in sample inlet systems, improved software, and the advent of special purpose mass spectrometers have improved the utility of MS instruments. here, the authors discuss this new utility.
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Raman Spectroscopy and Chemical Bonding of BaFCl, BaFBr, and BaFlWe explain how to characterize barium fluorohalides with Raman spectroscopy.
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Cartesian Geometry EDXRF for Analysis of ULSDThis application note demonstrates the performance for the measurement of sulfur in ultra-low sulfur diesel using full polarization in 90° Cartesian geometry EDXRF.
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Radio Frequency Glow Discharge Optical Emission Spectroscopy: Depth Profiling Analysis of Thin Anodic Alumina Films as Potential Reference Materials (PDF)The need for reference materials that can be applied in the area of thin films analysis has long been realized but is still, in general, under-addressed. Alumina films of single-micrometer thickness, having either fine distributions of impurities or delta function impurity marker layers, can be prepared routinely by anodic oxidation of electropolished aluminum specimens in appropriate electrolytes. Selected films were examined by transmission electron microscopy (TEM) and analyzed by radio frequency glow discharge optical emission spectroscopy (rf-GD-OES), providing very rapid, yet high-resolution, depth-resolved analysis of these electrically insulating materials.
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Aerial Hyperspectral Imaging by BaySpec OCI Hyperspectral ImagersBaySpec’s OCI-UAV hyperspectral imagers are ultra-compact, easily deployable, high-performance hyperspectral cameras designed specifically for use on small unmanned aerial vehicles (UAVs), to monitor the details of spatial, temporal, and spectral representation of ground objects.
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Characterizing Graphene with Cost-Effective Raman SystemsThis application note explores the characterization of graphene with an affordable modular Raman spectrometer system using the StellarNet HYPER-Nova.
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The Hyphenation of HILIC, Reversed-Phase HPLC, and Atmospheric-Pressure-Ionization MSHydrophilic interaction liquid chromatography (HILIC) and reversed-phase high performance liquid chromatography (HPLC) are complementary techniques in the separation of organic molecules with a broad band of polarity. Both separation variants can be operated easily with volatile and water-miscible solvents (for example, ammonium acetate aqueous solution and acetonitrile). Thus, a hyphenation of both liquid chromatographic techniques with atmospheric pressure ionization (API) and mass spectrometry (MS) seems to be a consequent step.
