Spectroscopy-06-01-2005

Spectroscopy

The Baseline: The Solar Spectrum

June 01, 2005

Columns: The Baseline

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Spectroscopists separate light from the sun into spectra and look for the presence or absence of particular lines that give hints regarding its chemical composition. The same method can be applied to studying the composition of other matter in the universe.

AFM Measurement of Step Kinetics for the Growth and Dissolution of Crystallites

June 01, 2005

Articles

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This paper discusses two atomic force microscopy (AFM) techniques that have been used successfully to quantify step movement: direct and indirect measurement. The benefits and difficulties associated with each method are discussed.

A High-Volume, High-Throughput LC–MS Therapeutic Drug Monitoring System

June 01, 2005

Articles

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Therapeutic drug monitoring is performed routinely by liquid chromatography–mass spectrometry (LC–MS) using instrumentation and methods originally developed and systematically configured for the high-volume, high-throughput analysis of drugs of abuse. An example of LC–MS monitoring of the drug clozapine and its metabolite, desmethylclozapine, is detailed along with a description of the overall system architecture, workflow, and maintenance routines that support a large-scale clinical therapeutic drug monitoring program. The relative advantages of LC–MS over immunoassay and LC–UV, the current standard techniques for therapeutic drug monitoring, are discussed in the light of these results.