Author | Jerry Zweigenbaum

Articles

Comprehensive Screening, Confirmation, and Quantification of Organic Pesticides in Foods by GC–MS and LC–MS

November 01, 2008

Special Issues

Article

This article provides an overview of the instrument platforms, tools, and workflow for analyzing pesticides.

A High-Volume, High-Throughput LC–MS Therapeutic Drug Monitoring System

June 01, 2005

Spectroscopy

Article

Therapeutic drug monitoring is performed routinely by liquid chromatography–mass spectrometry (LC–MS) using instrumentation and methods originally developed and systematically configured for the high-volume, high-throughput analysis of drugs of abuse. An example of LC–MS monitoring of the drug clozapine and its metabolite, desmethylclozapine, is detailed along with a description of the overall system architecture, workflow, and maintenance routines that support a large-scale clinical therapeutic drug monitoring program. The relative advantages of LC–MS over immunoassay and LC–UV, the current standard techniques for therapeutic drug monitoring, are discussed in the light of these results.