ADME/Tox Profiling Using Coulometric Electrochemistry and Electrospray Ionization Mass Spectrometry (PDF)

June 1, 2003
Ray Smith

Ian Acworth

John Waraska

Paul Gamache

Ryan McCarthy


Spectroscopy, Spectroscopy-06-01-2003,

The authors discuss the use of serial coulometric flow cells coupled online with electrospray ionization mass spectrometry in predictive assays for absorption, distribution, metabolism, excretion, toxicity (ADME/Tox), and stability implemented at early stages of drug discovery.