ADME/Tox Profiling Using Coulometric Electrochemistry and Electrospray Ionization Mass Spectrometry (PDF)

June 1, 2003

The authors discuss the use of serial coulometric flow cells coupled online with electrospray ionization mass spectrometry in predictive assays for absorption, distribution, metabolism, excretion, toxicity (ADME/Tox), and stability implemented at early stages of drug discovery.