Special Issues
The authors show how a multivariate curve resolution algorithm, called SIMPLe-to-use Interactive Self-modeling Mixture Analysis (SIMPLISMA), can facilitate the quantitative and qualitative analysis of difficult samples, and apply the algorithm to a technically challenging Raman spectra series for carbamazepine polymorphs.
Real-Time Chemometric Analysis of Multicomponent Bioprocesses Using Raman Spectroscopy
In this study, a glycerol-fed, lab-scale E. coli bioprocess producing representative pharmaceutical compounds was monitored offline with a portable, high-sensitivity Raman spectrometer.