NMR in Action: Damodaran Krishnan Achary on Interdisciplinary Applications

In this video, Damodaran Krishnan Achary discusses the evolving role of nuclear magnetic resonance (NMR) spectroscopy at the University of Pittsburgh and the skills new users need to succeed. While the NMR facility initially focused on small-molecule solution studies, Achary has expanded its use across disciplines, supporting researchers in biology, geology, radiology, chemical engineering, pharmacy, and materials science. This interdisciplinary approach has enabled applications ranging from biomolecular structure characterization to solid-state investigations of battery materials and other complex systems.

Achary emphasizes that supporting a diverse user base requires more than instrument operation. “When someone comes to you, you have to explain what NMR can do for them,” he said, highlighting the importance of matching the experimental technique to the research question—whether that involves multi-dimensional solution experiments, solid-state MAS NMR, or specialized nuclei detection. This guidance not only optimizes experimental design but also fosters collaborations across scientific fields.

For new users, keeping pace with advances in pulse sequences, probe technology, and acquisition strategies is critical. Achary advises against relying on outdated methods: “You should not be running your grandfather’s experiments.” He recommends leveraging resources such as user meetings, vendor webinars, application notes, and specialized courses to stay current with modern instrumentation and experimental strategies.

Achary’s insights underscore how NMR spectroscopy extends far beyond traditional applications, providing a versatile and quantitative platform for probing molecular structure, dynamics, and interactions across a wide array of chemical, biological, and materials systems.