Spectroscopy-04-01-2017

Excited state dynamics provides an intrinsic molecular contrast of samples examined. These dynamics can be monitored by pump probe spectroscopy which measures the change in transmission of a probe beam induced by a pump beam. With superior detection sensitivity, chemical specificity and spatial-temporal resolution, pump probe microscopy is an emerging tool for functional imaging of non-fluorescent chromophores and nanomaterials. This article reviews the basic principle, instrumentation strategy, data analysis methods, and applications of pump probe microscopy. A brief outlook is provided.

Data integrity requires a multilayered approach that runs throughout a regulated organization. Here we discuss the laboratory level.

In addition to primary alcohols there exist secondary and tertiary alcohols.

This article reviews recent advances in the application of Transmission Raman Spectroscopy (TRS) to pharmaceutical analysis. The TRS technique overcomes subsampling limitations of conventional Raman spectroscopy and enables rapid non-invasive volumetric analysis of intact pharmaceutical tablets and capsules in a quantitative manner with relevance to quality and process control applications. Although only recently introduced to this area its uptake and the breadth of applications are rapidly growing with regulatory approvals for use of this technology in quality control of manufactured pharmaceutical products recently being granted.

Although weakness in the metals and mining industry has challenged the market for spectroscopy instruments in 2016, the demand for environmental and food testing have been robust, forging growth for key technologies such as ICP and ICP-MS.

Duncan Graham of the University of Strathclyde is pushing the limits of what can be achieved using functionalized nanoparticles and SERS, in applications such as cholera detection, lipid profiling in cancer cells, and assessing the efficacy of anti-cancer drugs.

Jennifer S. Brodbelt of the University of Texas at Austin discusses the development and application of photodissociation mass spectrometry for studying biological molecules such as peptides, proteins, nucleic acids, oligosaccharides, and lipids.

Click the title above to open the Spectroscopy April 2017 regular issue, Vol 32 No 4, in an interactive PDF format.