LC-MS

April 12th 2024

Here are the top five articles that the editors of Spectroscopy published this week.

November 14th 2023

Award recipient John McLean of Vanderbilt University said hybrid techniques do not exist purely as combinations of letters, slashes, and hyphens—they have been built on the shoulders of decades’ worth of analysis intended to refine and simplify workflow.

March 1st 2020

The presence of per- and polyfluoralkyl substances (PFAS) in water is an important health and environmental concern. Liquid chromatography–mass spectrometry (LC–MS) has been established as the most suitable technology for monitoring these substances. A method is described, using EPA 8327, for PFAS analysis in groundwater, surface water, and wastewater.

July 1st 2017

There is growing interest in the determination of endogenous proteins in biological samples for diagnostic purposes, because a concentration increase or decrease of such proteins can allows us to monitor the state of a pathological condition such as cancer. Immunocapture LC–MS/MS analysis combines the workflow of conventional immunological assays with LC–MS analysis. This article describes typical challenges, such as cross reactivity and the mass spectrometer’s dynamic range, as well as the advantages of isoform differentiation and multiplexing.