Appendix VIII: Raman

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Spectroscopy, Spectroscopy-05-01-2015, Volume 30, Issue 5


Manufacturer: BaySpec, Inc.
Product name: Dual-band Agility
Raman analyzer with active trigger probe
For: Laboratory analysis, process applications, handheld, or portable use
Weight: 14 lbs
Dimensions: 10-in x 12.5-in x 5.5-in (305 mm x 380 mm x 168 mm)
Measurement mode: Raman scattering
Software name: Agile 2020
Software features: Available as separate product, 21 CFR Part 11-compliant, cGMP compliant, may be used with other equipment, compatible with other manufacturers' equipment
Unique features: The world's first dual-band portable Raman instrument enabling users to measure "real-world" samples. Measurements can be conducted in a light tight chamber using liquid vial, solid down, solid side, solid up, rotating, or fiber optic probe.
New this year: The Agility is now available with a ruggedized active trigger probe. The probe tips can be adapted for different sampling environments.
Suggested applications: IQ/OQ/PQ in pharmaceutical and industrial plants, forensics, CBE detection, didactic teaching tool, and research and development.


Manufacturer: BaySpec, Inc.
Product name: RamSpec-HR
1064 High-rez Raman system
Software name: Spec 2020
Software features: Available as separate product, may be used with other equipment, compatible with other manufacturers' equipment
For: Laboratory analysis, process applications, handheld, or portable use
Weight: 54 cm x 54 cm x 30 cm
Dimensions: 22 Kg
Measurement mode: 1064 nm laser Raman
Unique features: High-resolution dispersive 1064 nm Raman spectroscopy. Fast, compact, turn-key, and no sample preparation. Raman fiber probe option and direct sampling option available.
Suggested applications: Samples with high fluorescence (for example, plant-based, tissues), in-situ chemical analysis, in-line monitoring, petrochemicals, fuels and biofuels, biomedical research, pharmaceuticals, material science, forensic labs


Manufacturer: BaySpec, Inc.
Product name: MovingLab
Dual-band portable Raman microscope
Software: Spec2020
Software features: Available as separate product, may be used with other equipment, compatible with other manufacturers' equipment
For: Laboratory analysis, process applications, handheld, or portable use
Weight: 22 lbs
Dimensions: 305 x 305 x 381 (12-in. x 12-in. x 15-in.)
Measurement mode: 532 and 1064 nm Laser Raman
Unique features: This Raman microscope comes with two excitation laser excitations, that is, two lasers from 532, 785, 1064 nm, with fully automated laser switching. It can be equipped with both visible and NIR laser excitations. The 1064 excitation option avoids fluorescence for both laboratory and field measurement.
New this year: Added dual band capability for the previous single band model
Suggested applications: Samples with high fluorescence (for example, plant-based, tissues), in-situ chemical analysis, in-line monitoring, petrochemicals, fuels and biofuels, biomedical research, pharmaceuticals, material science, and forensic labs.


Manufacturer: BioTools Inc.
Product name: µ-BioRAMAN and Mobile-µ-Raman
Raman spectrometer
For: Laboratory analysis, process applications, handheld, or portable use
Weight: ~30 lbs
Dimensions: 18 ¼-in x 9 ¼-in x 14-in (L x W x H)
Software name: µ-BioRAMAN and Mobile-µ-Raman
Unique features: Small footprint, flip up cover, battery, piezo stage, samespot optical system, highly sensitive detector, PZT stage for mapping. Superb signal-to-noise ratio, clear spectra and rapid scanning for Raman maps
Suggested applications: Applications for the classroom, the lab and the field: infusion centers, physicians office, hospitals; biologics: SERS; Raman microscopy; applications across industries: forensics, academia, art and archeology, pharma, chemical, food and water safety testing; trace detections of entities; spectral discrimination enabling differentiations between strains of bacteria.




Manufacturer: Bruker Optik GmbH
Product name: BRAVO
Handheld Raman spectrometer
For: Handheld portable use
Weight: 1.5 kg (3.3 lbs)
Dimensions: 27.0 (W) x 15.6 (D) x 6.2 (H) cm
Measurement mode: Dispersive Raman spectroscopy with proprietary fluorescence mitigation
Software name: OPUS
Software features: Available as separate product, 21 CFR Part 11-compliant, cGMP compliant
Unique features: Sequentially shifted excitation (SSE) (patented) mitigates fluorescence, duo LASER excitation provides largest spectral range, IntelliTip ensures using always the proper measuring tip, LASER class 1M product for all measurement modes, intuitive and guided touch screen operation.
Suggested applications: Raw material verification and identification in pharma market.


Manufacturer: B&W Tek, Inc.
Product name: i-Raman Pro
Raman Spectrometer
For: Laboratory analysis, handheld, or portable use
Weight: ~19.5 lbs (~8.8 kg)
Dimensions: 15.7-in. x 10.2-in. x 9.8-in. (40 cm x 26 cm x 25 cm)
Software name: BWSpec Mobile
Unique features: The i-Raman Pro is a portable smart Raman spectrometer, using a high quantum efficiency (QE) cooled (-25 °C) CCD array detector for high dynamic range. This portable Raman spectrometer delivers an improved signal-to-noise ratio for applications requiring over 30 min of integration time. The compact mobile design provides users with research grade Raman capabilities anywhere.
Suggested applications: Art and archaeology, bioscience and medical diagnosis, pharmaceutical industry, Raman microscopy, polymers and chemical processes, environmental science, forensic analysis, gemology, geology and mineralogy, food and agriculture industry, semiconductor and solar industry, narcotics, and SERS



Manufacturer: Edinburgh Instruments Ltd
Product name: LP980
Nanosecond transient absorption spectrometer
For: Laboratory analysis
Measurement mode: Transient absorption, laser-induced fluorescence, laser-induced breakdown spectroscopy, Raman measurements
Software name : L900 and FAST Advanced software
Software features: Available as separate product, cGMP compliant
Unique features: A first of its kind on the market, the LP980 allows for the measurement of transient absorption, laser-induced fluorescence and phosphorescence, Raman spectroscopy and lasr-induced breakdown spectroscopy (LIBS) all in one instrument. The LP980 sets the standard for technical performance required in a premier research instrument, offering unsurpassed measurement capabilities across a broad range of chemical, physical, and biological applications.
Suggested applications: Transient absorption and photobleaching, triplet-triplet annihilation, oxygen quenching of transient absorption decays, spectrally dependent transient kinetics, time-resolved absorption spectra, time-resolved fluorescence and phosphorescence, LIBS, ground and excited-state Raman.



Manufacturer: JASCO
Product name: NRS-4100 Series
Raman Spectrometers
For: Laboratory analysis
Measurement mode: Raman scattering, temperature/atmosphere controlled measurements
Software name: Spectra Manager II
Software features: 21 CFR Part 11-compliant, cGMP compliant
Unique features: New, compact, and easy-to-use NRS-4100 series laser Raman Spectrometer. The NRS-4100 has many of the great features and performance of its larger siblings with a whole host of new technological innovations to streamline collection of Raman spectra.
Suggested applications: Materials analysis, chemical analysis, mapping/imaging applications, pharmaceutical, biological/biochemical analyses, polymers, particulate contamination, organic/inorganic/organometallic analyses


Manufacturer: Metrohm
Product name: Metrohm Instant Raman Analyzer - Mira
Raman spectrometer
For: Laboratory analysis, process applications, handheld, or portable use
Weight: 1.2 lbs
Dimensions: 12.5 × 8.5 × 3.9 cm (5 × 3.35 × 1.5-in.)
Measurement mode: Raman scattering from vial or multiple focal distance reflectance adapters for measurement in polybag or glass container.
Software: Mira Cal software is a controlling and data management software for the Mira instrument. Mira Cal allows to conveniently store, manage, reprocess, and exchange data between multiple Mira instruments. The software allows the user to activate/deactivate purchased commercial libraries. or use software to build up your own library which can be transferred between multiple Mira instruments. This "open library" principle allows the user to utilize the Mira spectrometer in the most flexible way possible.
Software features: cGMP compliant
Unique features: The Mira Basic package with the vial holder is the only handheld Raman instrument in the market with a laser class I safety feature. The covering also contains a safety interlock. The Mira packages offer three quick-change inserts, which can be rapidly exchanged within the base system. These options include an integrated vial holder that are inserted into the Mira spectrometer for measurement.
New this year: Two different adapters with different focal lengths are offered with Mira. As the adapters are changed, the laser focus is moved to a different distance. Two point-and-shoot adapters that enable the measurement of powders, granulates, and liquids in polybags or colored glass containers are included. This open library principle allows the customer to build and use their own libraries. The amount of library storage space is large - over 400,000 samples can be accommodated. Mira provides an extensive collection of Raman spectra of more than 9000 pure compounds. These are suitable for not only identifying unknown Raman spectra, but also characterizing a whole range of different materials. This complete library is subdivided into 21 industry specific sublibraries, which can be combined and added to custom library as necessary and transfer it to any number of Mira spectrometers.
Suggested applications: Mira can be used for identification, screening, and confirmation of materials at all phases of the manufacturing process in chemical, refinery, petrochemical, personal care, and polymer industries.


Manufacturer: Ondax, Inc
Product name: THz-Raman Microscope System
Confocal Raman microscope
For: Laboratory analysis
Measurement mode: Confocal Raman
Software features: May be used with other equipment: (Kaiser, Horiba, Andor/Princeton spectrometers), compatible with other manufacturers' equipment: (Kaiser, Horiba, Andor, Princeton spectrometers, Nikon/Leica/Olympus/Zeiss scientific microscopes)
Unique features: Combines chemical detection and structural analysis into one instrument. A 976-nm excitation source significantly reduces auto-fluorescence, avoiding the need for InGaAs detectors typically required to measure fluorescent materials. Using, the TR-MICRO-976 and XLF-CLM-976 deliver clear low-frequency Stokes and anti-Stokes spectral analysis over a range of ± 5–500 cm-1 when used with conventional Si detector-based spectrographs, enabling reliable identification of molecular structure characteristics of fluorescent materials.
New this year: 976 nm is a new excitation wavelength for the product, that mitigates auto-fluorescence within the range of standard silicon CCD cameras.
Suggested applications: Applications include pharmaceutical analysis, explosives detection and source attribution, nanomaterials, petrochemicals, agricultural and industrial chemicals, forensics, and material science.



Manufacturer: Rigaku Raman Technologies
Product name: Progeny ResQ
Raman spectrometer
For: Handheld/portable use
Weight: 1.6 kg
Dimensions: 29.9 cm x 8.1 cm x 7.4 cm
Measurement mode: Handheld with optimal docking station.
Unique features: Its 1064-nm excitation laser enables users to measure colored solids and liquids as well as measuring substances through containers. Offers the industry's most comprehensive library with over 12,000 compounds including CWAs, explosives, TIC/TIM, and narcotics. Large, easily readable display and one-button operation makes it easy to use while wearing Level A and MIL-STD-810G protective suits.
Suggested applications: Intuitive chemical detection analyzer for use by emergency responders, law enforcement professionals, and the military to respond to incidents including hazardous materials, threat defense, and narcotics. Identify threats at the point of need, including a measurement delay timer.


Manufacturer: TechnoSpex Pte Ltd
Product name: uRaman
Raman spectrometer
For: Laboratory analysis
Software name: uSoft/uSoft-Map
Unique features: Integrates Raman spectroscopy into existing upright microscope functions; DIC, phase contrast, dark field. All compact and affordable . Multiple wavelength, stackable module; gives users the flexibility to connect to the different types of detectors via optical fiber cable. The spectrometer may range from a compact spectrometer to high end research grade spectrometer.
Suggested applications: Ideal for SERS, semiconductor, pharmaceutical, gemology, agriculture, forensic, biomedical, and materials


Manufacturer: Thermo Fisher Scientific
Product name: Gemini
Handheld Raman/mid-IR analyzer
For: Handheld or portable use
Measurement mode: ATR and Raman scattering
Unique features: The first and only handheld integrated Raman and FT-IR instrument. Combines ease of ATR sampling with the complementary power of Raman in a field-portable device. The Gemini Analyzer is certified to MIL-STD-810G.


Manufacturer: Tornado Spectral Systems
Product name: HyperFlux PRO
Raman Spectrometer
For: Process applications
Weight: 30 lbs
Dimensions: 19-in. x 18-in. x 7-in.
Measurement mode: Transmission
Software features: 21 CFR Part 11-compliant
Unique features: The HyperFlux PRO, which incorporates TSS's patented HTVS technology, is an-online and at-line process Raman analyzer designed for real time, remote, and unattended operations.
Suggested applications: Short chains and aromatic for refining (oil and gas), crystallization analysis (pharmaceutical), analysis of flowing powders in Raman in a blender, (pharmaceutical) monitoring of PET extrusion by in-line Raman spectroscopy, reaction monitoring and control by Raman spectroscopy


Manufacturer: WITec GmbH
Product name: apyron
Automated Raman imaging
Measurement mode: Reflection
High spectral resolution in 3D confocal Raman imaging, apyron surpasses previous standards of performance. Fully automated Raman system includes laser wavelength selection and adjustment of all associated spectrometer and microscope components. A new 600 mm focal length spectrometer specific for automated Raman imaging, enables measurements at even very low light intensities and high resolution.
Suggested applications: Materials and polymer sciences, thin films, coatings, pharmaceutics and cosmetics, archaeology and geoscience, forensics. Multi-user labs, industry labs with recurring experimental scenarios, and Raman newcomers.