In the ICH Q3D Guideline for Elemental Impurities, 24 elemental impurities were identified as elements of concern due to their toxicity, and permitted daily exposure limits (PDE) were established. This application note presents a quick, accurate analysis of these elements.
An upcoming talk at SciX 2026 Conference will describe a new multimodal platform using laser ablation inductively coupled plasma–mass spectrometry (LA-ICP-MS) elemental mapping that can detect nanoparticles and microplastics in biological tissue.
John Philip Walters, Ph.D. (1938-2026), was an analytical chemist who spent 17 years researching the physics of spark-discharge emission spectroscopy at the University of Wisconsin-Madison before moving to St. Olaf College in 1982, where he became best known for pioneering a role-playing undergraduate laboratory model that had students take on professional roles to mirror real analytical-chemistry work. His 1991 three-part series on the approach in Analytical Chemistry earned him the ACS Division of Analytical Chemistry's J. Calvin Giddings Award in 1993, and he continued extending his understand-the-system teaching philosophy into computer-controlled instrumentation well into his later career.