IMS for Cleaning Verification (PDF)

January 2, 2005
Joey Buaron

Jose Faria

Kent Payne

Wayne Fawber

Reno DeBono

Azhar Mahmood

Special Issues

Special Issues, Special Issues-01-02-2005, Volume 0, Issue 0

The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.

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