In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)

Article

Special Issues

Spectroscopy SupplementsSpecial Issues-01-02-2005
Volume 0
Issue 0

The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.