In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)

Article

Special Issues

Spectroscopy SupplementsSpecial Issues-01-02-2005
Volume 0
Issue 0

The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.

To view a PDF of this article from the Spectroscopy Online archives, click this link.

Articles in this issue
IMS for Cleaning Verification (PDF)
Post-Tableting NIR Analysis: A Look at PAT Applicability to the Output of Solid Dosage Forms (PDF)
PAT, NeSSI, and Sample Conditioning Systems: State of the Technologies and Future Directions (PDF)
Chemometrics and PAT: What Does It All Mean? (PDF)
In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)
Stand PAT (PDF)
Near-Infrared Chemical Imaging and the PAT Initiative (PDF)
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