Special Issues
The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.
High-Speed Laser MS for Precise, Prep-Free Environmental Particle Tracking
April 21st 2025Scientists at Oak Ridge National Laboratory have demonstrated that a fast, laser-based mass spectrometry method—LA-ICP-TOF-MS—can accurately detect and identify airborne environmental particles, including toxic metal particles like ruthenium, without the need for complex sample preparation. The work offers a breakthrough in rapid, high-resolution analysis of environmental pollutants.