Register Now: Advances in Spectroscopy for Pharma and Biopharmaceutical Analysis Symposium
|Articles|January 2, 2005

Spectroscopy Supplements

  • Special Issues-01-02-2005
  • Volume 0
  • Issue 0

In-Line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy (PDF)

The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.


Related to this article

Atoms Don't Lie–The Remaking of Atomic Spectroscopy, © Hallie -chronicles-stock.adobe.com
Atomic spectroscopy has quietly gone from counting elements in bulk to counting single nanoparticles, imaging tissue at the micrometer scale, and reading Martian rocks from several meters away. The instruments got smaller, the software got smarter, and the questions they can now answer got a lot more interesting.