QA/QC PHARMACEUTICAL SOLUTIONS - Cary 8454 UV-Visible Spectroscopy System

The Agilent Cary 60 UV-Vis spectrophotometer is the new, improved successor to the award-winning Cary 50 UV-Vis. In this short review, this instrument platform was evaluated for its potential to measure small (40 µL) samples of methylene blue in situ during exposure to high-intensity UV irradiation. Methylene blue is combined with other compounds used in a variety of applications, including use in cosmetics and sun screen products and environmental remediation in contaminated air and polluted water.

2D materials such as graphene and transition metal dichalcogenides are well-suited to investigation by Raman and SEM. Examples of both are presented in the following.

Better sample prep leads to better analysis; discover the keys to a better battery digest, leading to better analysis, for samples from R&D testing to quality control.

This study demonstrates the through-opaque-container analysis capability of the Agilent Vaya handheld Raman spectrometer by performing measurements on a range of common excipients and active ingredients within blue barrels. Spatially offset Raman spectroscopy (SORS) is the unique Agilent technology that is the basis of the unique Vaya container subtraction algorithm. This technology can optimize the spectra to provide the clearest signature of contents with the minimum amount of container interference. Verification of raw materials directly through plastic barrels provides efficient raw material identification (RMID) workflows in the warehouse without the need for specialized personnel or controlled sampling environments.

Handheld Raman spectrometers can distinguish raw materials through transparent and opaque packaging containers. This application note demonstrates the use of the handheld Agilent Vaya Raman raw material identity verification system based on spatially offset Raman spectroscopy (SORS) for chemical ID verification and testing of mRNA lipid nanoparticle (LNP) components through transparent glass and white opaque polyethylene containers.