Yingchan Guo Previews Her Talk on Improving Structural Identification of Phosphatidylcholines

Yingchan Guo is a researcher in the Prentice Research Group at the University of Florida (Gainesville), joining the laboratory in 2021 after completed her BS in Chemistry at the Beijing University of Chemical Technology (Beijing, China) in 2020 (1). The Prentice Group, headed by Boone M. Prentice, specializes in bioanalytical mass spectrometry (MS), with a focus on developing advanced instrumentation and experimental and computational methods to probe the molecular basis of health and disease (1).

Guo’s recent work spans several methods in mass spectrometry, including imaging mass spectrometry (IMS), tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LC-MS), and gas-phase ion/ion reactions. Through these techniques, Guo contributes to pushing forward the sensitivity, specificity, spatial resolution, and interpretative power of MS-based analyses of biological tissues, lipids, and glycan structures (1).

Guo is set to deliver a talk tomorrow titled, “Manipulation of Gas-Phase Charge Inversion Ion/Ion Reaction Kinetics for Enhanced Phospholipid Identification in Imaging Mass Spectrometry” (2). In her talk, Guo will describe a novel charge inversion ion/ion reaction using a multiply charged reagent ion, 1,2,4,5-tetrakis(4-carboxylphenyl)benzene (TCPB), to improve structural identification of phosphatidylcholines (PCs) in IMS (2).

In the below clip, Guo previews her talk on Tuesday and gives her reaction of the conference thus far.

This interview clip is part of our interview with Guo. To stay up to date with the latest coverage of the 2025 SciX Conference, click here.

You can also learn more about the work Yingchan Guo contributed to by reading one of her team’s published papers.

• Characterizing the Energy Surfaces of Competing Pathways in Gas-Phase Charge Inversion Ion/Ion Reactions Involving Cationized Lipids and Anionic Diacids. J. Am. Soc. Mass Spectrom. 2025, 36 (10), 2103-2116. DOI: 10.1021/jasms.5c00123
• Extended Similarity Methods for Efficient Data Mining in Imaging Mass Spectrometry. Digit. Discov. 2024, 3 (4), 805-817. DOI: 10.1039/d3dd00165b
• Enhancing Spatial Resolution in Tandem Mass Spectrometry Ion/Ion Reaction Imaging Experiments through Image Fusion. J. Am. Soc. Mass Spectrom. 2024, 35 (8), 1797-1805. DOI: 10.1021/jasms.4c00144
• A Mass Spectrometry-Based Assay for Mouse IgG N-Glycan Screening in Biofluids. Anal. Bioanal. Chem. 2025, 417 (20), 4525-4535. DOI: 10.1007/s00216-025-05994-x

References

1. Prentice Research Group, Yingchan Guo. University of Florida. Available at: https://prentice.chem.ufl.edu/guo/ (accessed 2025-10-06).
2. SciX Conference, Manipulation of Gas-Phase Charge Inversion Ion/Ion Reaction Kinetics for Enhanced Phospholipid Identification in Imaging Mass Spectrometry. SciX Conference. Available at: https://www.scixconference.org/2025-final-program (accessed 2025-10-06).