Author | Libo Wang

Articles

Native Measurement of a Biotherapeutic without Interference from Excipients Using Microfluidic Modulation Spectroscopy

August 01, 2019

Special Issues

Article

A new infrared spectroscopy technique, microfluidic modulation spectroscopy (MMS), delivers reproducible protein characterization over close to four orders of magnitude in protein concentration (from 0.1 to 200 mg/mL). This technique characterizes samples from the earliest stages of development through to manufacture.

Enhanced Protein Structural Characterization Using Microfluidic Modulation Spectroscopy

February 01, 2019

Special Issues

Article

This article introduces a new infrared (IR) technique, microfluidic modulation spectroscopy (MMS), that is designed to address these needs, and presents data from measurements of commercially available proteins. The data demonstrate significant increases in sensitivity, dynamic range, and utility for the determination of protein similarity (fingerprinting), quantitation, protein secondary structure, and protein stability and aggregation through thermal and chemical denaturation methods.

Enhanced Protein Structural Characterization Using Microfluidic Modulation Spectroscopy

July 01, 2018

Spectroscopy

Article

This article introduces a new IR technique, microfluidic modulation spectroscopy (MMS), that is designed to address the needs in biotherapeutics, and presents data from measurements of commercially available proteins.