
A hybrid Uniform Design and process-data calibration strategy improves Raman-based PLS model development for real-time monitoring of ultrafiltration/diafiltration and in vitro transcription steps in biopharmaceutical manufacturing.
Lin Zhang, Ph.D., is an algorithm development manager at Thermo Fisher Scientific in Tewksbury, Massachusetts. His expertise includes chemometrics, multivariate calibration, and spectroscopic method development for process analytical technology and portable analytical instruments. He holds a Ph.D. in Analytical Chemistry and an M.S. in Computer Science from Ohio University, as well as M.S. and B.S. degrees in Analytical Chemistry from Hunan University.

A hybrid Uniform Design and process-data calibration strategy improves Raman-based PLS model development for real-time monitoring of ultrafiltration/diafiltration and in vitro transcription steps in biopharmaceutical manufacturing.