RedShiftBio

Articles

Protein secondary structure, without the fuss

October 17, 2019

Monoclonal Antibody Analysis by Microfluidic Modulation Spectroscopy in a Complex Formulation Buffer (1 to 150 mg/mL)

October 01, 2019

Celldex utilized MMS to successfully observe the HOS of monoclonal antibody samples in complex buffer systems including excipients such as amino acids and sugars.

Thermal Denaturation Analysis of Bovine Serum Albumin over Wide Concentration Range by Microfluidic Modulation Spectroscopy

October 01, 2019

BSA samples analyzed at different concentrations to study heat induced thermal denaturation. Results show excellent reproducibility between sample replicates, concentrations.

Introduction to the AQS3TMpro: Enabled by Microfluidic Modulation Spectroscopy

October 01, 2019

Novel IR technique, microfluidic modulation spectroscopy, to address the requirements of development laboratories for high-quality higher-order structure assessment

Conformation Change of a Monoclonal Antibody in Real Time, Mimicking Low-pH Hold Viral Inactivation

October 01, 2019

This webinar presents a study mimicking the viral inactivation low pH hold used in purification of mAbs.

Structural Characterization of the Insulin-Degrading Enzyme by Microfluidic Modulation Spectroscopy

October 01, 2019

A new bioanalytical technique called microfluidic modulation spectroscopy is used to probe the backbone structure of IDE in the absence and presence of ATP and insulin.

Microfluidic Modulation Spectroscopy (MMS) Fills an Analytical Gap with a Lower LoQ for Measuring Protein Misfolds and Structural Similarity

October 01, 2019

This whitepaper explores MMS as a high-resolution method for the determination of protein HOS.

Antibodies and Antibody-Drug Conjugate Higher-Order Structures Revealed

October 01, 2019

This webinar shows a demonstration of some of the key advantages of MMS for assessment of higher-order structure in therapeutic antibodies and antibody-drug conjugates.

Repeatability, Concentration Linearity, and High-Order Structure Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy (MMS)

October 01, 2019

An IgG1 sample was analyzed at different concentrations. The results in this poster from Pfizer, demonstrate high repeatability and precision of the diffAU spectra.