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The noninvasive discrimination of powdered root material belonging to the Polygala genus and an adulterant is presented. The quality of the approach is assessed for attenuated total reflectance mid-infrared spectroscopy and diffuse reflectance near-infrared spectroscopy. Due to the pharmaceutical importance of Polygala related plant material, conclusions are drawn towards a laboratory independent discrimination of the samples.

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The noninvasive discrimination of powdered root material belonging to the Polygala genus and an adulterant is presented. The quality of the approach is assessed for attenuated total reflectance mid-infrared spectroscopy and diffuse reflectance near-infrared spectroscopy. Due to the pharmaceutical importance of Polygala related plant material, conclusions are drawn towards a laboratory independent discrimination of the samples.

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This study reported a combined use of ordinary Fourier transform-infrared spectroscopy (FT-IR) in conjunction with partial-least-square (PLS) multivariate regression for accurate determination of the percent compositions of four essential oils (EOs) (wintergreen, tea tree, rosemary, and lemon eucalyptus oils) that were adulterated either with lemongrass essential oil (LO) or peppermint essential oil (PO). The FT-IR spectra of the calibration sample sets of known compositions of adulterated EOs with LO or PO were measured and subjected to PLS multivariate regression analysis. The simplicity, low-cost, and high accuracy of the protocol makes it appealing for routine industrial quality assurance of consumable goods.

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This study reported a combined use of ordinary Fourier transform-infrared spectroscopy (FT-IR) in conjunction with partial-least-square (PLS) multivariate regression for accurate determination of the percent compositions of four essential oils (EOs) (wintergreen, tea tree, rosemary, and lemon eucalyptus oils) that were adulterated either with lemongrass essential oil (LO) or peppermint essential oil (PO). The FT-IR spectra of the calibration sample sets of known compositions of adulterated EOs with LO or PO were measured and subjected to PLS multivariate regression analysis. The simplicity, low-cost, and high accuracy of the protocol makes it appealing for routine industrial quality assurance of consumable goods.

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This study reported a combined use of ordinary Fourier transform-infrared spectroscopy (FT-IR) in conjunction with partial-least-square (PLS) multivariate regression for accurate determination of the percent compositions of four essential oils (EOs) (wintergreen, tea tree, rosemary, and lemon eucalyptus oils) that were adulterated either with lemongrass essential oil (LO) or peppermint essential oil (PO). The FT-IR spectra of the calibration sample sets of known compositions of adulterated EOs with LO or PO were measured and subjected to PLS multivariate regression analysis. The simplicity, low-cost, and high accuracy of the protocol makes it appealing for routine industrial quality assurance of consumable goods.

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This study reported a combined use of ordinary Fourier transform-infrared spectroscopy (FT-IR) in conjunction with partial-least-square (PLS) multivariate regression for accurate determination of the percent compositions of four essential oils (EOs) (wintergreen, tea tree, rosemary, and lemon eucalyptus oils) that were adulterated either with lemongrass essential oil (LO) or peppermint essential oil (PO). The FT-IR spectra of the calibration sample sets of known compositions of adulterated EOs with LO or PO were measured and subjected to PLS multivariate regression analysis. The simplicity, low-cost, and high accuracy of the protocol makes it appealing for routine industrial quality assurance of consumable goods.

Latest:

This study reported a combined use of ordinary Fourier transform-infrared spectroscopy (FT-IR) in conjunction with partial-least-square (PLS) multivariate regression for accurate determination of the percent compositions of four essential oils (EOs) (wintergreen, tea tree, rosemary, and lemon eucalyptus oils) that were adulterated either with lemongrass essential oil (LO) or peppermint essential oil (PO). The FT-IR spectra of the calibration sample sets of known compositions of adulterated EOs with LO or PO were measured and subjected to PLS multivariate regression analysis. The simplicity, low-cost, and high accuracy of the protocol makes it appealing for routine industrial quality assurance of consumable goods.

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Microplastics from clothing, abrasive action on plastics, or engineered microbeads as found in some exfoliating cosmetics are showing up in many environmental systems. FT-IR microscopy is a useful tool in the analysis of microplastics, providing visual information, particle counts, and particle identification.

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Moxidectin formulations help to reduce hair loss and irritation due to parasite worms in animals. So Estimation of Moxidectin in hair is important to evaluate therapeutic levels, distribution & accumulation, however estimation is also useful to evaluate harm to birds when they eat animal hair. Hence Moxidectin estimation is required for pharmacokinetic as well as environmental exposure study. Objective of the present work is to develop a rapid, selective method for the estimation of Moxidectin in Cattle Hair by LC-MS/MS. Oxcarbazepine used as a internal standard. Moxidectin extracted from cattle hair by liquid-liquid extraction using Sorenson’s Buffer as digestion solvent for incubation & methyl tert-butyl ether as an extraction solvent. Detection was performed over the range 0.026 to 1.000 ng/mG using MRM in positive polarity at unit resolution under turbo ion spray whereas separation was achieved on Kinetex 100 x 4.6 mm, 5u EVO C18 100A column with Methanol : 10mM Amonium formate pumped as gradient flow with 4.50min run time. Q1 is 640.45 whereas Q3 is sum of 528.50 and 498.50. Validation parameters shown reliable results. Method is applied for the estimation of Moxidectin in cattle Hair.

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Moxidectin formulations help to reduce hair loss and irritation due to parasite worms in animals. So Estimation of Moxidectin in hair is important to evaluate therapeutic levels, distribution & accumulation, however estimation is also useful to evaluate harm to birds when they eat animal hair. Hence Moxidectin estimation is required for pharmacokinetic as well as environmental exposure study. Objective of the present work is to develop a rapid, selective method for the estimation of Moxidectin in Cattle Hair by LC-MS/MS. Oxcarbazepine used as a internal standard. Moxidectin extracted from cattle hair by liquid-liquid extraction using Sorenson’s Buffer as digestion solvent for incubation & methyl tert-butyl ether as an extraction solvent. Detection was performed over the range 0.026 to 1.000 ng/mG using MRM in positive polarity at unit resolution under turbo ion spray whereas separation was achieved on Kinetex 100 x 4.6 mm, 5u EVO C18 100A column with Methanol : 10mM Amonium formate pumped as gradient flow with 4.50min run time. Q1 is 640.45 whereas Q3 is sum of 528.50 and 498.50. Validation parameters shown reliable results. Method is applied for the estimation of Moxidectin in cattle Hair.

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This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

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This application note details a GC-MS-based analytical method for the qualitative and quantitative determination of Irganox 1076 and 1010 in polyethylene.

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This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

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The Diablo 5000A RTGA-MS allows the process stream to be seen in real-time and provides quantitative data with reliable mass information. The result is visualization.

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This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

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This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

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This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.

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How to create a liquid chromatography–tandem mass spectrometry (LC–MS-MS) system using mass spectrometers, a high performance liquid chromatography (HPLC) binary pump system, and an autosampler

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Systematic toxicological analysis is an important step in medicolegal investigations of death, poisoning, and drug use. The primary goal is the detection and confirmation of potentially toxic compounds in evidence. This article describes a workflow using nontargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) for reliable compound identification.

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Systematic toxicological analysis is an important step in medicolegal investigations of death, poisoning, and drug use. The primary goal is the detection and confirmation of potentially toxic compounds in evidence. This article describes a workflow using nontargeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) for reliable compound identification.

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The development of novel, nondestructive technologies for rapid analysis of evidence discovered at crime scenes is pertinent to our criminal justice system to solve the millions of violent crimes that occur each year. Without a witness, establishing the precise timeline of a crime is difficult. Therefore, technologies based on sensitive, nondestructive techniques are needed to evaluate evidence and create such a timeline. We propose the use of Raman spectroscopy to analyze the age of bloodstains for potential use as a forensics tool. Previous studies have revealed Raman spectroscopy is sensitive to changes in blood analyte concentration and different oxidative states of hemoglobin. Raman spectroscopy could allow for rapid comparison of spectra from blood stains of unknown age to spectra of known age with high temporal accuracy. Though further investigation into other substrates and biochemical components should be performed, our study reveals Raman spectroscopy has the potential to accurately and nondestructively determine the age of a bloodstain for use in criminal investigations.

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The development of novel, nondestructive technologies for rapid analysis of evidence discovered at crime scenes is pertinent to our criminal justice system to solve the millions of violent crimes that occur each year. Without a witness, establishing the precise timeline of a crime is difficult. Therefore, technologies based on sensitive, nondestructive techniques are needed to evaluate evidence and create such a timeline. We propose the use of Raman spectroscopy to analyze the age of bloodstains for potential use as a forensics tool. Previous studies have revealed Raman spectroscopy is sensitive to changes in blood analyte concentration and different oxidative states of hemoglobin. Raman spectroscopy could allow for rapid comparison of spectra from blood stains of unknown age to spectra of known age with high temporal accuracy. Though further investigation into other substrates and biochemical components should be performed, our study reveals Raman spectroscopy has the potential to accurately and nondestructively determine the age of a bloodstain for use in criminal investigations.

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The development of novel, nondestructive technologies for rapid analysis of evidence discovered at crime scenes is pertinent to our criminal justice system to solve the millions of violent crimes that occur each year. Without a witness, establishing the precise timeline of a crime is difficult. Therefore, technologies based on sensitive, nondestructive techniques are needed to evaluate evidence and create such a timeline. We propose the use of Raman spectroscopy to analyze the age of bloodstains for potential use as a forensics tool. Previous studies have revealed Raman spectroscopy is sensitive to changes in blood analyte concentration and different oxidative states of hemoglobin. Raman spectroscopy could allow for rapid comparison of spectra from blood stains of unknown age to spectra of known age with high temporal accuracy. Though further investigation into other substrates and biochemical components should be performed, our study reveals Raman spectroscopy has the potential to accurately and nondestructively determine the age of a bloodstain for use in criminal investigations.

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The development of novel, nondestructive technologies for rapid analysis of evidence discovered at crime scenes is pertinent to our criminal justice system to solve the millions of violent crimes that occur each year. Without a witness, establishing the precise timeline of a crime is difficult. Therefore, technologies based on sensitive, nondestructive techniques are needed to evaluate evidence and create such a timeline. We propose the use of Raman spectroscopy to analyze the age of bloodstains for potential use as a forensics tool. Previous studies have revealed Raman spectroscopy is sensitive to changes in blood analyte concentration and different oxidative states of hemoglobin. Raman spectroscopy could allow for rapid comparison of spectra from blood stains of unknown age to spectra of known age with high temporal accuracy. Though further investigation into other substrates and biochemical components should be performed, our study reveals Raman spectroscopy has the potential to accurately and nondestructively determine the age of a bloodstain for use in criminal investigations.

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The development of novel, nondestructive technologies for rapid analysis of evidence discovered at crime scenes is pertinent to our criminal justice system to solve the millions of violent crimes that occur each year. Without a witness, establishing the precise timeline of a crime is difficult. Therefore, technologies based on sensitive, nondestructive techniques are needed to evaluate evidence and create such a timeline. We propose the use of Raman spectroscopy to analyze the age of bloodstains for potential use as a forensics tool. Previous studies have revealed Raman spectroscopy is sensitive to changes in blood analyte concentration and different oxidative states of hemoglobin. Raman spectroscopy could allow for rapid comparison of spectra from blood stains of unknown age to spectra of known age with high temporal accuracy. Though further investigation into other substrates and biochemical components should be performed, our study reveals Raman spectroscopy has the potential to accurately and nondestructively determine the age of a bloodstain for use in criminal investigations.

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Miniaturization of analytical instruments of various forms of spectroscopy has improved dramatically in recent years mainly because of the requirements in certain areas such as space, industrial, and environmental research. Research into miniaturization is primarily driven by the need to reduce the instrumental space and costs by reducing the consumption of expensive reagents and by increasing throughput and automation. Like other fields, analytical systems have also been affected by novel ideas and unprecedented advances in the microelectronics leading to miniaturization of different components in recent years. This article presents an overview of the current developments in the miniaturization of analytical instruments for mainly detecting metals at extremely low concentration levels, with some important examples from areas such as space, mineral exploration, the environment, and pharmaceuticals, focusing primarily on advancements as well as the challenges that have impacted from some of the major international manufacturers.