Pittcon Review, Appendix X: Spectroscopy (other)
Additional information from the Spectroscopy (other) section of the Pittcon Review article.
Manufacturer: Excellims Corporation
Product name: AIMS2100 ESI-HPIMS
Ion mobility spectrometer
For: Lab and process analysis
New this year: When AIMS2100 is added-on to an existing MS or LC–MS system, it provides a simultaneous orthogonal IMS separation method for structure elucidation with MS analysis for peak identification. The AIMS2100 enables isomer determination functionality to resolve isobaric peaks, extending the analytical capabilities of established instrument suites.
Portable: 7H x 7W x 13D in.
Accessory/component: The spectrometer can be used simultaneously with any system capable of liquid sample handling
Special features: Mobility and mass data are generated on the same sample or LC peak to seamlessly
Suggested applications: Compound identification in drug discovery and development processes, reaction monitoring, content uniformity, purity checking, and cleaning verification
Primary benefits: The AIMS2100 provides a new dimension for sample analysis and offers significant performance advantages in isomer separation to otherwise mature technologies. Adds structure determination capabilities to existing separation systems.
Unique features: Separates isomers and analyzes samples without chromophores that UV detectors miss.
Manufacturer: Excellims Corporation
Product name: GA2100 high-performance ion mobility spectrometer (HPIMS)
Ion mobility spectrometer
For: Lab and process analysis
New this year: A Directspray electrospray ionization (ESI) source enables users to analyze samples directly from standard syringes.
Portable: 18.5H x 15W x 18.4D in.
Accessory/component: ESI ionization source that can be directly interfaced to an autosampler for batch sample processing
Description: Interfaces typical autosampler systems with the ESI source combine electrospray with IMS.
Special features: A common analysis can be completed in seconds with only a few microliters of sample
Suggested applications: At-line or on-line process analysis; compound identification, reaction monitoring, content uniformity, purity checking, on site environmental monitoring, on site food safety inspection, and cleaning verification
Primary benefits: Separates compounds by size and structural shape
Unique features: User-interchangeable sample introduction and ionization methods tailored to their application.
Manufacturer: Horiba Scientific
Product name: Microvolume Accessory
Accessory for all HORIBA fluorescence spectrofluorometers
For: Lab analysis
New this year: The Microvolume Accessory allows any HORIBA spectrofluorometer to perform measurements on as little as 1 μL of sample.
Accessory/component: Cuvette adapter
Measurement mode: Steady-state and lifetime fluorescence (90°)
Description: This drop-in accessory fits into the cuvette holder of any HORIBA fluorometer and allows ultralow-volume measurements.
Special features: Optimized optics allow highest efficiency of signal collection. A removable sample chamber.
Suggested applications: synthesized/purified molecule analysis; bodily fluids analysis; immunoassay development; protein synthesis process control; nanomaterial characterization
Primary benefits: The Microvolume Accessory gives the user the advantages of both a low-cost microvolume add-on to their existing fluorometer and the sensitivity of a full-size-cuvette instrument.
Unique features: Easy to clean, resistant to carryover.
Manufacturer: Horiba Scientific
Product name: Fluorolog EXTREME AND Fluorcube EXTREME
Supercontinuum laser-powered spectrofluorometers
For: Lab analysis
New this year: first integration of a supercontinuum white-light laser into a commercial spectrofluorometer. Fully integrated optically and software-wise
Measurement mode: Steady-state and lifetime fluorescence.
Special features: Plug-and-play simplicity, optimized opto-mechanical coupling, complete software integration
Suggested applications: NIR analysis of photon/phonon migration processes, singlet oxygen measurements; large diameter carbon nanotube analysis; multilabeled cell fluorescence.
Primary benefits: Flexibility in selecting excitation wavelength between visible to over 2 μm, optimized steady-state fluorescence spectroscopy.
Unique features: Software controls laser power and repetition rate of the laser source.
Manufacturer: JASCO
Product name: HDX -High-Throughput CD Measurement System
Circular dichroism spectrometer
For: Laboratory analysis
Measurement mode: Circular dichroism, absorbance, and fluorescence
Specialty accessorydescription: This commercially available circular dichroism measurement system allows fully automated measurements from 192 microplate wells. In addition to CD measurements Absorbance and Fluorescence are also possible
Special features: Automated thermal ramping, Sample recovery and batch processing of data
Suggested applications: Screening, quality control of biological products, Secondary structure analysis, thermal denaturation and protein structural characterization.
Primary benefits: Complete automation for multiple samples with batch processing of secondary structure and melting point determinations
Unique features: Works in circular dichroism (CD) mode as well as UV–vis absorbance and fluorescence
Manufacturer: picoSpin, LLC (Cole-Parmer is the exclusive international distribution partner)
Product name: picoSpin 45
45 MHz Miniature Benchtop NMR spectrometer
New this year: This is the world's first commercial miniature NMR spectrometer.
For: Laboratory analysis
Dimensions: <4.8 kg (10.5 lb) / 7.0 x 5.75 x 11.5 in. (shoebox size)
Description: FT-NMR 1H proton spectrometer and 19F. Primarily utilized as a spectrometer, is also relaxometry-capable.
Special features: Inexpensive, portable benchtop system for. Fully programmable pulse sequencer, 20-μL sample volume, users only require a web browser to interface, control, and archive data.
Suggested applications: Education (organic chemistry and instrumental analysis), lecture demonstration, reaction analysis, analyzing oxygen or moisture sensitive chemistries in a glove box
Getting accurate IR spectra on monolayer of molecules
April 18th 2024Creating uniform and repeatable monolayers is incredibly important for both scientific pursuits as well as the manufacturing of products in semiconductor, biotechnology, and. other industries. However, measuring monolayers and functionalized surfaces directly is. difficult, and many rely on a variety of characterization techniques that when used together can provide some degree of confidence. By combining non-contact atomic force microscopy (AFM) and IR spectroscopy, IR PiFM provides sensitive and accurate analysis of sub-monolayer of molecules without the concern of tip-sample cross contamination. Dr. Sung Park, Molecular Vista, joined Spectroscopy to provide insights on how IR PiFM can acquire IR signature of monolayer films due to its unique implementation.
Deep Level Transient Spectroscopy Reveals Influence of Defects on 2D Semiconductor Devices
April 25th 2024A recent study used deep level transient spectroscopy to investigate the electrical response of defect filling and emission in monolayer metal-organic chemical vapor deposition (MOCVD)-grown materials deposited on complementary metal-oxide-semiconductor (CMOS)-compatible substrates.
