Managing the challenges of analyzing brine solutions of variable concentrations using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) equipped with argon gas dilution

This application note details the analysis of various brine solutions, containing up to 25% w/w dissolved salt, using robust ICP-MS instrumentation operated with the next generation Argon Gas Dilution (AGD) accessory. These high matrix samples were analyzed directly, without manual dilution, eliminating error prone and time- consuming preparation and handling steps. The developed method was rigorously tested for performance and reliability demonstrated through excellent quality control, matrix spike and internal standard recoveries for an analysis of 120 samples of 2.5% w/w brine solution.