Thermo Fisher Scientific

Articles

This note demonstrates a fast analytical method for the determination of major and trace elements in ternary cathode material of lithium batteries using ICP-OES.


Elemental Analysis of Lithium Ion Batteries 

Identification of microplastics with the new Nicolet RaptIR FTIR Microscope

http://www.spectroscopyonline.com/spec_w/diversity

Single-cell analysis by inductively coupled plasma–mass spectrometry (SC-ICP-MS) refers to a powerful technique that can provide unique information about the elemental composition of individual cells. This knowledge is of growing importance in fields of toxicology, molecular biology, and drug development. During the last decade, elemental analysis of single cells has benefitted from improvements in the ICP-MS hardware, such as increased sensitivity and reduced backgrounds (translating into lower detection limits) and scanning speed. However, a limiting factor for this application is the number of intact cells that can be transported into the plasma and subsequently detected from a sample. With recent development of dedicated hardware solutions enabling high transport efficiencies for single cells, considerable improvements have been achieved, but counting statistics can still be a limiting factor for some applications, especially when compared to fluorescence flow cytometry.

This presentation will cover the fundamentals of single-cell analysis by ICP-MS, with a focus on the analysis of cell suspensions. Sample preparation, data treatment, limitations, current approaches, and improvements in sample introduction systems will be discussed, together with some examples of the newest applications in the field and practical tips.

Understand how ICP-MS can be used to analyze the elemental content of individual cells

See how this analysis can complement the results obtained by other techniques in the laboratory

Discover how the analysis of elements in single cells can help to better understand biological processes

Learn how to prepare samples and understand the fundamental concepts of data evaluation

Researchers investigating biological processes by means of cell cultures

Analysts looking at expanding their analytical capabilities

Lab leaders searching to improve their processes in bioprocessing


Post-Doctoral Researcher
University of Oviedo


Mario Corte’s research is focused on single-particle and single-cell elemental analysis of both metal-labelled cells and their elemental content. He obtained his PhD from the University of Oviedo in Spain in 2017. After gaining experience at the Federal Institute for Materials Research and Testing (BAM) in Berlin and at the University of Vienna, he currently works as a post-doctoral researcher at the group of Mass Spectrometry and Biomedical Analysis (EMAB) at the University of Oviedo and the Health Research Institute of Asturias (ISPA).

Webcasts

Thursday December 2, 2021 at 11am EST| 8am PST| 4pm GMT|5pm CET
How can we obtain deeper insight into processes in individual cells? Join this webcast to find out more about a new application of ICP-MS. 


Single-Cell ICP-MS: A Tool to Explore Biological Diversity

Interferences Explained for ICP-OES

Protein concentration prediction in cell cultures

Enabling real-time release of final products in manufacturing of biologics

This app note describes how, by using nitrate isotope fingerprints, it is possible to monitor water quality and trace the sources of pollution related to human activity.


Identifying Nitrate Pollution Sources by Isotope Fingerprints

This note demonstrates the suitability of ICP-OES for fast, sensitive, and robust elemental analysis of water samples, following the DIN EN ISO 11885:2009 requirements.

Fast and Robust Assessment of Water Quality

This Smart Note demonstrates how isotope fingerprints support forensic investigations on
human, criminal, environmental, ecological, food, and archaeological materials.
