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Inorganic Products: Mining Ores, Catalysts, Superalloys, and Ceramics
August 17th 2016The Milestone UltraWAVE can digest up to 22 different sample types simultaneously. The high temperature and pressure capability enables a complete digestion of nearly all inorganic sample types that need to be analyzed for trace metals.
Micro Sample Measurement using UV-Vis Spectroscopy and an Optical Microscope
August 11th 2016There is a need to optically characterize even smaller components and materials; placing these items in the standard UV-Vis sample compartment can be challenging. This note describes how very small samples can be routinely, accurately, and successfully characterized using UV-Vis combined with a standard optical microscope.
Discrimination of Lipids in Heart Tissue using DESI HRMS MSI
July 20th 2016Mass Spectrometric Imaging (MSI) using DESI provides molecular imaging without the interference of the matrix required for MALDI and offers the advantage of preserving sample for further analysis. DESI coupled to High Resolution Accurate Mass (HRAM), is shown here to elucidate spatial distribution of lipids, protein, and metabolites in tissue sections and can provide confident and discriminate biomarker determinations.
Non-invasive Combustion Diagnostics
July 7th 2016PLIF, PIV and next generation imaging detectors - Combustion processes, if uncontrolled, are inherently inefficient and increasing the efficiency of combustion in engines, gas burners and furnaces is a significant challenge for the future due to limited fossil fuel resources and their effects on the environment.
Efficient Mitigation of Fluorescence in Raman Spectroscopy Using SSE™
July 6th 2016Handheld Raman spectrometers are now designed and built for practical everyday use in a vast array of applications. The new BRAVO by Bruker takes handheld Raman Spectroscopy to a new level, overcoming the limitations of previously available systems such as limited wavelength accuracy, non-safe laser usage and fluorescence interference. Now with BRAVO wavelength accuracy is significantly better than competitive devices resulting in the highest data consistency and the BRAVO incorporates new technology called Sequentially Shifted Excitation (SSE™) to mitigate fluorescence.
This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection. This work will demonstrate a simple methodology using automated solid-phase extraction (SPE) and HPLC coupled with mass spectrometric detection.
Implementation of MicroNIR PAT for Blend Monitoring
June 13th 2016A wireless NIR spectrometer is deployed on solid dose blending formulation for end-point monitoring. The MicroNIR PAT is democratizing the use NIR spectroscopy in pharmaceutical manufacturing facilitating Quality by Design (QbD) adoption.
GOOD LABORATORY PRACTICE Agilent Cary 8454 UV-Visible Spectroscopy System
June 13th 2016This note looks at specific components that require validation; the instrument, software, and validated test methods, and describes the features of the Agilent Cary 8454 UV-Visible system that is designed to meet the requirements of both initial and recurrent validation.
QA/QC PHARMACEUTICAL SOLUTIONS - Cary 8454 UV-Visible Spectroscopy System
June 13th 2016This note describes how the design of the Cary 8454 UV-Vis exceeds performance requirements stipulated by global pharmacopeia guidelines including USP and EP/BP. Configured for compliance, with 21 CFR Part 11, the instrument performs multi wavelength analysis, time-based kinetics assays, and routine QA/QC measurements.
Agilent Cary 630 FTIR Pharmacopoeia Compliance
June 13th 2016This application note demonstrates how Agilent’s Cary 630 FTIR easily meets the specifications of the US, European, Japanese, Chinese, Indian and International Pharmacopoeia. Its combination of compact size, design, intuitive and regulation-compliant software makes the Cary 630 FTIR an ideal instrument for pharmaceutical quality control.
THE DIODE ARRAY ADVANTAGE for Pharmaceutical QA/QC
June 13th 2016The Agilent Cary 8454 UV-Visible system is ideal for regulatory Pharma QA/QC applications, and can acquire a complete spectrum in less than 1 second. This technical note outlines both applications-based and technical considerations for choosing a diode array UV-Vis
Agilent Cary 630 FTIR Spectrometer Quickly Identifies and Qualifies Pharmaceuticals
June 13th 2016This application note describes a very sensitive classification method, partial least squares–discriminant analysis (PLS-DA), incorporated in Agilent innovative MicroLab software, to classify and qualify materials of interest with greater sensitivity and specificity than possible with simple library search methods.
Variable Angle Reflectance and Transmittance of Thin Film Coatings Using UV-Vis-NIR
June 8th 2016The ability to easily characterize thin films by variable angle transmission and reflection is very important in both the design/development process and in the final production. This note presents the use of UV-Vis-NIR spectroscopy to characterize film samples in the full spectral region, from UV to NIR.
Using MicromATR Vision™ for Food Analysis: Measurement of the Macro-Nutrients
June 1st 2016This application note describes the measurement of food macronutrients by diamond attenuated total reflectance (ATR) mid infrared spectroscopy. Specific examples include the measurement of sugar content of grapes (grape juice) and the measurement of fats in cheese, chocolate and milk.