Recent developments in sample inlet systems, improved software, and the advent of special purpose mass spectrometers have improved the utility of MS instruments. here, the authors discuss this new utility.
Time-of-Flight (TOF) is rapidly becoming the most popular method of mass separation for proteomics and conventional analytical chemistry. The development of very high temporal resolution ion detectors and low-cost high-speed digitizers has rendered this technique easily deployed and able to produce very high mass resolution. The performance of a TOF mass spectrometer is dependent upon a number of critical components. This article will focus on the ion detector.