Hongyan Chen


Online ATR-FT-IR for Real-Time Monitoring of the Aspirin Esterification Process in an Acid-Mediated Reaction

August 01, 2022

In this study, the measured spectra of acetic anhydride, acetic acid, salicylic acid, and aspirin are used for in situ monitoring of the progression of aspirin synthesis in a reaction system. Traditional methods such as HPLC and titration ultraviolet (UV) absorption are not optimal for such real-time monitoring because of long analytical times and complicated procedures. ATR-FT-IR offers an alternative solution that overcomes the shortcomings of traditional techniques.