Author | James Martosella

James Martosella is an R&D Scientist, Bioseparations, Agilent Technologies, Little Falls, Delaware.

Articles

New Sample Fractionation Strategies for Proteomic Analyses by LC–MS

November 01, 2006

Special Issues

Article

Mass spectrometry has long been a preferred tool for protein identification and biomarker discovery, but preparation of biological samples remains a challenge. Hindrances include the wide range of protein concentrations, sample complexity, and loss or alteration of important proteins due to sample handling. This article describes recent developments in sample fractionation technologies that are overcoming these challenges in interesting ways and are enabling in-depth proteomic studies that were not possible in the past.