Peter B. Ehmer is with Johnson & Johnson Pharmaceutical Research & Development, 2340 Beerse, Belgium.
Measurement of Metabolic Stability Using SIM and Identification of Metabolites by Data-Dependent full-Scan MS-MS and CNL Scanning
In this article, the role of a triple-quadrupole mass spectrometer in performing in vitro studies of compound metabolic stability and identification of Phase I and II metabolites is demonstrated.