Stephane Mabic


Why and How to Avoid Ionic Contamination in Water Used for LC–MS Analyses

July 01, 2015

Ionic contaminants in the water used in UHPLC analyses with MS detection method lead to adduct formation and reduced analytical signals because of ion suppression. In MS, the preferred ion type is the protonated molecular ion, especially in peptide analysis, since the partially mobile proton charge enables more meaningful fragmentation analysis, as compared to a sodiated peptide ion.