Susan Hodi

Recent advances in Raman instrumentation have resulted in the development of easy-to-use and efficient handheld Raman analyzers. Most of the commercially available handheld Raman devices utilize 785 or 1064 nm excitation. This paper directly demonstrates the performance of 532 nm handheld Raman (versus 785 and 1064 nm) for the analysis of biopharmaceuticals for structure and counterfeit testing as well as explosive detection (TSA screening and CSI applications). The results presented here will contribute to recognition of 532 nm Raman excitation as a highly attractive option for a rapid “in-place” analysis in the field.