Thomas G. Mayerhofer

Jurgen Popp, Thomas Mayerhofer, and colleagues at Leibniz IPHT and Friedrich Schiller University Jena introduce the Personalized Optical Digital Twin (PODT), a Photonics21 contribution to Europe's Virtual Human Twin ecosystem that connects molecular photonics—Raman blood analysis, coherent Raman tissue imaging, and multimodal endomicroscopy—with longitudinal physiology and clinical data. Drawing on the published multicenter INTELLIGENCE trials, the authors argue that technical feasibility and clinical utility must be evaluated separately as the field moves toward Europe's FP10 research agenda.

In the final clip of our conversation with Thomas Mayerhöfer, he talks about attenuated total reflectance (ATR) spectroscopy's sensitivity to nanometer-thick layers, and its connection to spectroscopic ellipsometry.

In this interview clip, we explore how an optical model accounts for thin-layer thickness on the order of the penetration depth so spectra reflect partial-reflection effects.

Is sample thickness important for signal detection? The answer is yes, and in this interview segment, Thomas Mayerhofer of Leibniz Institute of Photonic Technology explains why.

In this interview clip, Thomas Mayerhofer discusses why he re-evaluated the evanescent field in attenuated total reflectance (ATR) spectroscopy.

What is the evanescent field and how does it relate to attenuated total reflectance (ATR) spectroscopy? Thomas Mayerhofer explains.

In this tutorial, Thomas G. Mayerhöfer and Jürgen Popp introduce complex-valued chemometrics as a more physically grounded alternative to traditional intensity-based spectroscopy measurement methods. By incorporating both the real and imaginary parts of the complex refractive index of a sample, this approach preserves phase information and improves linearity with sample analyte concentration. The result is more robust and interpretable multivariate models, especially in systems affected by nonlinear effects or strong solvent and analyte interactions.

The Bouguer-Beer-Lambert law has its limitations and it doesn't always properly reflect the physical phenomena at play. This article examines the law's limitations.

Peak shifts in infrared spectra may occur for many reasons other than structural changes on the molecular or unit cell level. Here, we discuss several examples.